Klotho mitigates cyclosporine A (CsA)-induced epithelial–mesenchymal transition (EMT) and renal fibrosis in rats

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• 作者：Qi-feng Liu ; Jian-ming Ye ; Li-xia Yu…
• 关键词：Klotho ; Cyclosporine A ; Epithelial–mesenchymal transition ; Renal fibrosis
• 刊名：International Urology and Nephrology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：49
• 期：2
• 页码：345-352
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Nephrology; Urology;
• 出版者：Springer Netherlands
• ISSN：1573-2584
• 卷排序：49

文摘

PurposeKlotho deficiency is implicated in various kidney diseases, including renal fibrosis. The aim of this study was to investigate the effect of Klotho administration on epithelial–mesenchymal transition (EMT) and renal fibrosis induced by cyclosporine A (CsA) in rats.