Translational selection in human: more pronounced in housekeeping genes
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- 作者：Lina Ma (1)
Peng Cui (2)
Jiang Zhu (3)
Zhihua Zhang (1)
Zhang Zhang (1)
1. CAS Key Laboratory of Genome Sciences and Information ; Beijing Institute of Genomics ; Chinese Academy of Sciences ; No.1 Beichen West Road ; Chaoyang District ; Beijing ; 100101 ; China
2. Division of Chemical and Life Sciences & Engineering ; King Abdullah University of Science and Technology ; Jeddah ; Thuwal ; 23955-6900 ; Kingdom of Saudi Arabia
3. Department of Pathology ; Massachusetts General Hospital and Harvard Medical School ; Boston ; Massachusetts ; 02114 ; USA - 关键词：Translational selection ; Codon usage bias ; Expression regulation ; Housekeeping gene ; Tissue ; specific gene
- 刊名：Biology Direct
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：9
- 期：1
- 全文大小：1,470 KB
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- 出版者：BioMed Central
- ISSN：1745-6150
文摘
Background Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular eukaryotes. Recent evidence has shown that translational selection is weakly operative in highly expressed genes in human and other vertebrates. However, it remains unclear whether translational selection acts differentially on human genes depending on their expression patterns. Results Here we report that human housekeeping (HK) genes that are strictly defined as genes that are expressed ubiquitously and consistently in most or all tissues, are under stronger translational selection. Conclusions These observations clearly show that translational selection is also closely associated with expression pattern. Our results suggest that human HK genes are more efficiently and/or accurately translated into proteins, which will inevitably open up a new understanding of HK genes and the regulation of gene expression. Reviewers This article was reviewed by Yuan Yuan, Baylor College of Medicine; Han Liang, University of Texas MD Anderson Cancer Center (nominated by Dr Laura Landweber) Eugene Koonin, NCBI, NLM, NIH, United States of America Sandor Pongor, International Centre for Genetic Engineering and biotechnology (ICGEB), Italy.