Purifying selection against gene conversions between the polyamine transport (TPO) genes of Saccharomyces species

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• 作者：Gowthami Sampathkumar (1)
  Guy Drouin (1)
  
• 关键词：Saccharomyces cerevisiae ; Saccharomyces paradoxus ; Saccharomyces mikatae ; Gene conversions ; Polyamine transport genes ; TPO genes ; Yeasts ; Negative selection
• 刊名：Current Genetics
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：61
• 期：1
• 页码：67-72
• 全文大小：774 KB
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• 作者单位：Gowthami Sampathkumar (1)
  Guy Drouin (1)
  
  1. D茅partement de biologie et Centre de recherche avanc茅e en g茅nomique environnementale, Universit茅 d鈥橭ttawa, 30 Marie Curie, Ottawa, ON, K1N 6N5, Canada
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbial Genetics and Genomics
  Microbiology
  Biochemistry
  Cell Biology
  Plant Sciences
  Proteomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0983

文摘

Saccharomyces species have five TPO genes, TPO1 through TPO5, coding for proteins that are involved in up taking or excreting intracellular spermine, putrescine or spermidine. Here, we investigate the evolutionary fate and functional impacts of gene conversions between these genes. Our results show that gene conversions occurred only between the TPO2 and TPO3 genes of the six Saccharomyces species we studied. They also show that these gene conversions occurred independently in all six species. The facts that they only occur between closely related genes having similar function, and that they are limited to the transmembrane domain of these proteins, suggest that they have little functional impact. These gene conversions therefore likely represent neutral mutations which are not subject to purifying selection.