Novel vs clinical organ preservation solutions: improved cardiac mitochondrial protection
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- 作者：Alice S. Ferng ; David Schipper ; Alana M. Connell…
- 关键词：Organ preservation solution ; Cardiac myoblasts ; Mitochondria ; Bioenergetics ; Somah ; Celsior ; Perfadex
- 刊名：Journal of Cardiothoracic Surgery
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：12
- 期：1
- 全文大小：830KB
- 刊物主题：Cardiac Surgery; Thoracic Surgery;
- 出版者：BioMed Central
- ISSN：1749-8090
- 卷排序：12
文摘
BackgroundHeart transplantation remains the gold standard for end-stage heart failure, with current ex vivo organ storage times limited to 4 to 6 h before critical tissue damage occurs. Many preservation solutions exist in an attempt to limit both ischemic and reperfusion damage. In order to compare the effects of various storage solutions, mitochondrial function can be used to provide a sensitive analysis of cellular metabolic function.