Regulation of heme biosynthesis and transport in metazoa

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• 作者：FengXiu Sun ; YongJiao Cheng ; CaiYong Chen
• 关键词：heme ; iron ; synthesis ; transport ; regulation
• 刊名：Science China Life Sciences
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：58
• 期：8
• 页码：757-764
• 全文大小：417 KB
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• 作者单位：FengXiu Sun (1)
  YongJiao Cheng (1)
  CaiYong Chen (1)
  
  1. College of Life Sciences and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, 310058, China
  
• 刊物主题：Life Sciences, general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1869-1889

文摘

Heme is an iron-containing tetrapyrrole that plays a critical role in regulating a variety of biological processes including oxygen and electron transport, gas sensing, signal transduction, biological clock, and microRNA processing. Most metazoan cells synthesize heme via a conserved pathway comprised of eight enzyme-catalyzed reactions. Heme can also be acquired from food or extracellular environment. Cellular heme homeostasis is maintained through the coordinated regulation of synthesis, transport, and degradation. This review presents the current knowledge of the synthesis and transport of heme in metazoans and highlights recent advances in the regulation of these pathways.