Homologue gene of bile acid transporters ntcp, asbt, and ost-alpha in rainbow trout Oncorhynchus mykiss: tiss

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• 作者：Koji Murashita (1)
  Yasutoshi Yoshiura (2)
  Shin-ichi Chisada (2)
  Hirofumi Furuita (1)
  Tsuyoshi Sugita (1)
  Hiroyuki Matsunari (1)
  Yasuro Iwashita (1)
  Takeshi Yamamoto (1)
  
• 关键词：Cloning ; Enterohepatic circulation ; Fish ; SLC10A1 ; SLC10A2 ; OST
• 刊名：Fish Physiology and Biochemistry
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：40
• 期：2
• 页码：511-525
• 全文大小：4,132 KB
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• 作者单位：Koji Murashita (1)
  Yasutoshi Yoshiura (2)
  Shin-ichi Chisada (2)
  Hirofumi Furuita (1)
  Tsuyoshi Sugita (1)
  Hiroyuki Matsunari (1)
  Yasuro Iwashita (1)
  Takeshi Yamamoto (1)
  
  1. Aquaculture Systems Division, National Research Institute of Aquaculture, Fisheries Research Agency, Tamaki, Mie, 519-0423, Japan
  2. Aquatic Animal Health Division, National Research Institute of Aquaculture, Fisheries Research Agency, Tamaki, Mie, 519-0423, Japan
  
• ISSN：1573-5168

文摘

Bile acid transporters belonging to the SLC10A protein family, Na+ taurocholate cotransporting polypeptide (NTCP or SLC10A1), apical sodium-dependent bile salt transporter (ASBT or SLC10A2), and organic solute transporter alpha (Ost-alpha) have been known to play critical roles in the enterohepatic circulation of bile acids in mammals. In this study, ntcp, asbt, and ost-alpha-1/-2 cDNA were cloned, their tissue distributions were characterized, and the effects of fasting and bile acid administration on their expression were examined in rainbow trout Oncorhynchus mykiss. The structural characteristics of Ntcp, Asbt, and Ost-alpha were well conserved in trout, and three-dimensional structure analysis showed that Ntcp and Asbt were similar to each other. Tissue distribution analysis revealed that trout asbt was primarily expressed in the hindgut, while ntcp expression occurred in the brain, and ost-alpha-1/-2 was mainly expressed in the liver or ovary. Although asbt and ost-alpha-1 mRNA levels in the gut increased in response to fasting for 4?days, ost-alpha-1 expression in the liver decreased. Similarly, bile acid administration increased asbt and ost-alpha-1 expression levels in the gut, while those of ntcp and ost-alpha-2 in the liver decreased. These results suggested that the genes asbt, ntcp, and ost-alpha are involved in bile acid transport in rainbow trout.