Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol
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- 作者：Y. Kimura ; J. Maeda ; M. Yamada ; K. Takahata ; K. Yokokawa ; Y. Ikoma…
- 关键词：Dopamine ; Dopamine transporters ; Positron emission tomography ; Mazindol ; Raclopride ; Fe ; PE2I ; Consciousness ; Psychological state
- 刊名：Psychopharmacology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：234
- 期：3
- 页码：323-328
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-2072
- 卷排序：234
文摘
RationaleThe beneficial effects of psychostimulant drugs in the treatment of psychiatric disorders occur because they increase the extracellular dopamine concentration by inhibiting re-uptake of extracellular dopamine at dopamine transporters. However, the psychological effects at low dopamine transporter occupancy have not been well demonstrated.