Transporter-mediated L-glutamate elimination from cerebrospinal fluid: possible involvement of excitatory amino acid transporters expressed in ependymal cells and choroid plexus epithelial cells

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• 作者：Shin-ichi Akanuma ; Tatsuhiko Sakurai ; Masanori Tachikawa…
• 关键词：Excitatory amino acid transporter ; EAAT1 ; EAAT3 ; Glutamine synthase ; Ependymal cells ; L ; glutamate ; Cerebrospinal fluid ; Blood ; cerebrospinal fluid barrier
• 刊名：Fluids and Barriers of the CNS
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：12
• 期：1
• 全文大小：1,665 KB
• 刊物主题：Neurosciences; Neurology;
• 出版者：BioMed Central
• ISSN：2045-8118

文摘

Background L-Glutamate (L-Glu) is the major excitatory neurotransmitter in the CNS, and its level in cerebrospinal fluid (CSF) is reported to be increased in neuroexcitatory diseases such as epilepsy. Since L-Glu concentration in the CSF is reported to be lower than that in plasma, it has been proposed that some mechanisms of L-Glu clearance from the CSF operate in the brain. The purpose of this study was to elucidate the major pathway of L-Glu elimination from rat CSF and the transporters responsible.