Transplantation of Cerebral Dopamine Neurotrophic Factor Transducted BMSCs in Contusion Spinal Cord Injury of Rats: Promotion of Nerve Regeneration by Alleviating Neuroinflammation
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- 作者：Hua Zhao ; Lei Cheng ; Xinwen Du ; Yong Hou ; Yi Liu ; Zhaoqiang Cui…
- 关键词：Spinal cord injury ; Cell therapy ; Bone marrow ; derived mesenchymal stem cells ; Cerebral dopamine neurotrophic factor ; Nerve regeneration ; Neuroinflammation
- 刊名：Molecular Neurobiology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：53
- 期：1
- 页码：187-199
- 全文大小：2,476 KB
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Lei Cheng (1)
Xinwen Du (3)
Yong Hou (1)
Yi Liu (1) (2)
Zhaoqiang Cui (2)
Lin Nie (1)
1. Department of Spine Surgery, Qilu Hospital of Shandong University, 250012, Jinan, China
2. Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, China
3. Department of Pediatric Surgery, Laizhou People’s Hospital, Laizhou, China - 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
- 出版者：Springer US
- ISSN：1559-1182
文摘
Traumatic spinal cord injury (SCI) causes neuron death and axonal damage resulting in functional motor and sensory loss, showing limited regeneration because of adverse microenvironment such as neuroinflammation and glial scarring. Currently, there is no effective therapy to treat SCI in clinical practice. Bone marrow-derived mesenchymal stem cells (BMSCs) are candidates for cell therapies but its effect is limited by neuroinflammation and adverse microenvironment in the injured spinal cord. In this study, we developed transgenic BMSCs overexpressing cerebral dopamine neurotrophic factor (CDNF), a secretory neurotrophic factor that showed potent effects on neuron protection, anti-inflammation, and sciatic nerve regeneration in previous studies. Our results showed that the transplantation of CDNF-BMSCs suppressed neuroinflammation and decreased the production of proinflammatory cytokines after SCI, resulting in the promotion of locomotor function and nerve regeneration of the injured spinal cord. This study presents a novel promising strategy for the treatment of spinal cord injury.