Pharmacological correction of microcirculation in rats suffering from traumatic brain injury

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• 作者：G. A. Boyarinov ; A. V. Deryugina ; E. I. Yakovleva ; R. R. Zaitsev…
• 关键词：mexicor ; traumatic brain injury ; electrophoretic mobility of erythrocytes ; morphology of the heart
• 刊名：Cell and Tissue Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：11
• 期：1
• 页码：65-72
• 全文大小：
• 刊物主题：Cell Biology;
• 出版者：Pleiades Publishing
• ISSN：1990-5203
• 卷排序：11

文摘

We investigated the effect of mexicor on functional indices of erythrocytes and the structure of myocardial microcirculation in rats suffering from traumatic brain injury (TBI). At 3, 7, and 12 days after TBI, we measured the concentration of 2,3-diphosphoglycerate (2,3-DPG) and the degree of erythrocyte aggregation and their electrophoretic mobility (EPME) in the blood of rats, as well as analyzing sections of the left ventricular myocardium. The first day after the TBI, we observed a decrease in EPME, an increase of erythrocyte aggregation, and an increase of 2,3-DFG concentration in erythrocytes as compared with intact animals. Intraperitoneal injection of mexicor led to an increase of EPME and 2,3-DPG level and reduced the aggregation of erythrocytes, which was most pronounced during the 3–7 days of the post-traumatic period. Improved functional parameters of erythrocytes were accompanied by the dynamics of regenerative processes in the heart. Intraperitoneal injection of mexicor restrained architectonic damage of microvasculature and cardiomyocytes ultrastructure of the left ventricular myocardium of the heart.