Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy

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• 作者：Travis Kotzur ; Roberto Benavides-Garcia…
• 关键词：Spermatogonial stem cells ; Infertility ; Cancer ; Late effects ; Fertility preservation ; Adjuvant
• 刊名：Reproductive Biology and Endocrinology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：1439KB
• 刊物主题：Reproductive Medicine; Endocrinology;
• 出版者：BioMed Central
• ISSN：1477-7827
• 卷排序：15

文摘

BackgroundThe lifesaving chemotherapy and radiation treatments that allow patients to survive cancer can also result in a lifetime of side-effects, including male infertility. Infertility in male cancer survivors is thought to primarily result from killing of the spermatogonial stem cells (SSCs) responsible for producing spermatozoa since SSCs turn over slowly and are thereby sensitive to antineoplastic therapies. We previously demonstrated that the cytokine granulocyte colony-stimulating factor (G-CSF) can preserve spermatogenesis after alkylating chemotherapy (busulfan).