Assessing the accuracy of using oscillating gradient spin echo sequences with AxCaliber to infer micron-sized axon diameters
详细信息 查看全文
- 作者：Morgan Mercredi ; Trevor J. Vincent…
- 关键词：Diffusion magnetic resonance imaging ; Computer simulation ; Neuroanatomy
- 刊名：Magnetic Resonance Materials in Physics, Biology and Medicine
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：30
- 期：1
- 页码：1-14
- 全文大小：
- 刊物主题：Imaging / Radiology; Computer Appl. in Life Sciences; Solid State Physics; Biomedical Engineering; Health Informatics;
- 出版者：Springer Berlin Heidelberg
- ISSN：1352-8661
- 卷排序：30
文摘
ObjectiveCurrent magnetic resonance imaging (MRI) axon diameter measurements rely on the pulsed gradient spin-echo sequence, which is unable to provide diffusion times short enough to measure small axon diameters. This study combines the AxCaliber axon diameter fitting method with data generated from Monte Carlo simulations of oscillating gradient spin-echo sequences (OGSE) to infer micron-sized axon diameters, in order to determine the feasibility of using MRI to infer smaller axon diameters in brain tissue.