5-HT1A gene promoter polymorphism and [18F]MPPF binding potential in healthy subjects: a PET study

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• 作者：Amélie Lothe (1) (2)
  Claudette Boni (3)
  Nicolas Costes (4)
  Sandrine Bouvard (1)
  Philip Gorwood (3)
  Franck Lavenne (4)
  Marion Alvarez (4)
  Philippe Ryvlin (1) (2) (5)
  
• 刊名：Behavioral and Brain Functions
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：6
• 期：1
• 全文大小：1215KB
• 参考文献：1. David SP, Murthy NV, Rabiner EA, Munafó MR, Johnstone EC, Jacob R, Walton RT, Grasby PM: A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. / J Neurosci 2005, 25:2586-0. CrossRef
  2. Lee M, Bailer UF, Frank GK, Henry SE, Meltzer CC, Price JC, Mathis CA, Putnam KT, Ferrell RE, Hariri AR, Kaye WH: Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women. / Mol Psychiatry 2005, 10:715-. CrossRef
  3. Lothe A, Boni C, Costes N, Gorwood P, Bouvard S, Le Bars D, Lavenne F, Ryvlin P: Association between triallelic polymorphism of the serotonin transporter and [18F]MPPF binding potential at 5-HT1A receptors in healthy subjects. / Neuroimage 2009, 47:482-2. CrossRef
  4. Zhuang ZP, Kung MP, Chumpradit S, Mu M, Kung HF: Derivatives of 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl-p-iodobenzamido)ethyl]pipera zine (p-MPPI) as 5-HT1A ligands. / J Med Chem 1994, 37:4572-. CrossRef
  5. Van Wijngaarden I, Tulp MT, Soudijn W: The concept of selectivity in 5-HT receptor research. / Eur J Pharmacol 1990, 188:301-2. CrossRef
  6. Zimmer L, Mauger G, Le Bars D, Bonmarchand G, Luxen A, Pujol JF: Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis. / J Neurochem 2002, 80:278-6. CrossRef
  7. Rbah L, Leviel V, Zimmer L: Displacement of the PET ligand 18F-MPPF by the electrically evoked serotonin release in the rat hippocampus. / Synapse 2003, 49:239-5. CrossRef
  8. Zimmer L, Riad M, Rbah L, Belkacem-Kahlouli A, Le Bars D, Renaud B, Descarries L: Toward brain imaging of serotonin 5-HT1A autoreceptor internalization. / Neuroimage 2004, 22:1421-. CrossRef
  9. Wu S, Comings DE: A common C-1018G polymorphism in the human 5-HT1A receptor gene. / Psychiatr Genet 1999, 9:105-. CrossRef
  10. Albert PR, Lemonde S: 5-HT1A receptors, gene repression, and depression: guilt by association. / Neuroscientist 2004, 10:575-3. CrossRef
  11. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Sequeira A, Kushwaha N, Morris SJ, Basak A, Ou XM, Albert PR: Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. / J Neurosci 2003, 23:8788-9.
  12. Parsey RV, Oquendo MA, Ogden RT, Olvet DM, Simpson N, Huang YY, Van Heertum RL, Arango V, Mann JJ: Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. / Biol Psychiatry 2006, 59:106-3. CrossRef
  13. Sullivan GM, Ogden RT, Oquendo MA, Kumar JS, Simpson N, Huang YY, Mann JJ, Parsey RV: Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. / Biol Psychiatry 2009, 66:223-0. CrossRef
  14. Hong CJ, Chen TJ, Yu YW, Tsai SJ: Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. / Pharmacogenomics J 2006, 6:27-3. CrossRef
  15. Costes N, Merlet I, Ostrowsky K, Faillenot I, Lavenne F, Zimmer L, Ryvlin P, Le Bars D: A 18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging. / J Nucl Med 2005, 46:1980-.
  16. Le Bars D, Lemaire C, Ginovart N, Plenevaux A, Aerts J, Brihaye C, Hassoun W, Leviel V, Mekhsian P, Weissmann D, Pujol JF, Luxen A, Comar D: High-yield radiosynthesis and preliminary in vivo evaluation of p-[18F]MPPF, a fluoro analog of WAY-100635. / Nucl Med Biol 1998, 25:343-0. CrossRef
  17. Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE: Consensus nomenclature for in vivo imaging of reversibly binding radioligands. / J Cereb Blood Flow Metab 2007, 27:1533-. CrossRef
  18. Gunn RN, Sargent PA, Bench CJ, Rabiner EA, Osman S, Pike VW, Hume SP, Grasby PM, Lammertsma AA: Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C]WAY-100635 for PET. / Neuroimage 1998, 8:426-0. CrossRef
  19. Costes N, Merlet I, Zimmer L, Lavenne F, Cinotti L, Delforge J, Luxen A, Pujol JF, Le Bars D: Modeling [18F]MPPF positron emission tomography kinetics for the determination of 5-hydroxytryptamine(1A) receptor concentration with multiinjection. / J Cereb Blood Flow Metab 2002, 22:753-5. CrossRef
  20. Parsey RV, Arango V, Olvet DM, Oquendo MA, Van Heertum RL, John Mann J: Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography. / J Cereb Blood Flow Metab 2005, 25:785-3. CrossRef
  21. Mazziotta J, Toga A, Evans A, Fox P, Lancaster J, Zilles K, Woods R, Paus T, Simpson G, Pike B, Holmes C, Collins L, Thompson P, MacDonald D, Iacoboni M, Schormann T, Amunts K, Palomero-Gallagher N, Geyer S, Parsons L, Narr K, Kabani N, Le Goualher G, Boomsma D, Cannon T, Kawashima R, Mazoyer B: A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). / Philos Trans R Soc Lond B Biol Sci 2001, 356:1293-22. CrossRef
  22. Friston KJ, Frith CD, Liddle PF, Frackowiak RSJ: Comparing functional (PET) images: the assessment of significant changes. / J Cereb Blood Flow Metab 1991, 11:690-.
  23. Friston KJ, Holmes AP, Worsley KJ, Poline JB, Frith CD, Frackowiak RJS: Statistical parametric maps in functional imaging: a general linear approach. / Hum Brain Mapp 1995, 3:189-10.
  24. Vergé D, Daval G, Marcinkiewicz M, Patey A, el Mestikawy S, Gozlan H, Hamon M: Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. / J Neurosci 1986, 6:3474-2.
  25. Pranzatelli MR, Durkin MM, Barkai AI: Quantitative autoradiography of 5-hydroxytryptamine1A binding sites in rats with chronic neonatal 5,7-dihydroxytryptamine lesions. / Brain Res Dev Brain Res 1994, 80:1-. CrossRef
  26. Huggenvik JI, Michelson RJ, Collard MW, Ziemba AJ, Gurley P, Mowen KA: Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein. / Mol Endocrinol 1998, 12:1619-9. CrossRef
  27. Bottomley MJ, Collard MW, Huggenvik JI, Liu Z, Gibson TJ, Sattler M: The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation. / Nat Struct Biol 2001, 8:626-3. CrossRef
  28. Mickey BJ, Ducci F, Hodgkinson CA, Langenecker SA, Goldman D, Zubieta JK: Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo. / J Neurosci 2008, 28:11354-. CrossRef
  29. Cosgrove KP, Mazure CM, Staley JK: Evolving knowledge of sex differences in brain structure, function, and chemistry. / Biol Psychiatry 2007, 62:847-5. CrossRef
  30. Nishizawa S, Benkelfat C, Young SN, Leyton M, Mzengeza S, de Montigny C, Blier P, Diksic M: Differences between males and females in rates of serotonin synthesis in human brain. / Proc Natl Acad Sci USA 1997, 94:5308-3. CrossRef
  31. Weiss LA, Abney M, Cook EH Jr, Ober C: Sex-specific genetic architecture of whole blood serotonin levels. / Am J Hum Genet 2005, 76:33-1. CrossRef
  32. Cidis Meltzer C, Drevets WC, Price JC, Mathis CA, Lopresti B, Greer PJ, Villemagne VL, Holt D, Mason NS, Houck PR, Reynolds CF, DeKosky ST: Gender-specific aging effects on the serotonin 1A receptor. / Brain Res 2001, 895:9-7. CrossRef
  33. Tauscher J, Verhoeff NP, Christensen BK, Hussey D, Meyer JH, Kecojevic A, Javanmard M, Kasper S, Kapur S: Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET. / Neuropsychopharmacology 2001, 24:522-0. CrossRef
  34. M?ller M, Jakobsen S, Gjedde A: Parametric and regional maps of free serotonin 5HT1A receptor sites in human brain as function of age in healthy humans. / Neuropsychopharmacology 2007, 32:1707-4. CrossRef
  35. Gozlan H, Thibault S, Laporte AM, Lima L, Hamon M: The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes. / Eur J Pharmacol 1995, 288:173-6. CrossRef
  36. Millet P, Moulin M, Bartoli A, Del Guerra A, Ginovart N, Lemoucheux L, Buono S, Fagret D, Charnay Y, Ibá?ez V: In vivo quantification of 5-HT1A-[18F]MPPF interactions in rats using the YAP-(S)PET scanner and a beta-microprobe. / Neuroimage 2008, 41:823-4. CrossRef
  
• 作者单位：Amélie Lothe (1) (2)
  Claudette Boni (3)
  Nicolas Costes (4)
  Sandrine Bouvard (1)
  Philip Gorwood (3)
  Franck Lavenne (4)
  Marion Alvarez (4)
  Philippe Ryvlin (1) (2) (5)
  
  1. CTRS-IDEE, Lyon, France
  2. INSERM U821, University Claude Bernard Lyon 1, INFL, Lyon, France
  3. INSERM U675, Faculté Xavier Bichat, University Paris VII, Paris, France
  4. CERMEP imagerie du vivant, Lyon, France
  5. Department of Functional Neurology and Epileptology, Hospices Civils de, Lyon, France
  
• ISSN：1744-9081

文摘

Background Previous Positron Emission Tomography (PET) studies of 5-HT1A receptors have shown an influence of several genetic factors, including the triallelic serotonin transporter gene-linked polymorphic region on the binding potential (BPND) of these receptors. The aim of our study was to investigate the relationship between a 5-HT1A promoter polymorphism and the binding potential of another selective 5-HT1A receptor antagonist, [18F]MPPF, in healthy subjects. Methods Thirty-five volunteers, including 23 women, underwent an [18F]MPPF scan and were genotyped for both the C(-1019)G 5-HT1A promoter polymorphism and the triallelic serotonin transporter gene-linked polymorphic region. We used a simplified reference tissue model to generate parametric images of BPND. Whole brain Statistical Parametric Mapping and raphe nuclei region of interest analyses were performed to look for an association of [18F]MPPF BPND with the C(-1019)G 5-HT1A promoter polymorphism. Results Among the 35 subjects, 5-HT1A promoter genotypes occurred with the following frequencies: three G/G, twenty-one G/C, and eleven C/C. No difference of [18F]MPPF BPND between groups was observed, except for two women who were homozygote carriers for the G allele and showed greater binding potential compared to other age-matched women over the frontal and temporal neocortex. However, the biological relevance of this result remains uncertain due to the very small number of subjects with a G/G genotype. These findings were not modified by excluding individuals carrying the S/S genotype of the serotonin transporter gene-linked polymorphic region. Conclusions We failed to observe an association between the C(-1019)G 5-HT1A promoter polymorphism and [18F]MPPF binding in healthy subjects. However our data suggest that the small number of women homozygote for the G allele might have greater [18F]MPPF BPND relative to other individuals. This finding should be confirmed in a larger sample.