Population data of 21 non-CODIS STR loci in Han population of northern China

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• 作者：Li Yuan (123) yuanliwcy@yahoo.com.cn
  Jianye Ge (4)
  Di Lu (3)
  Xue Yang (3)
• 关键词：Short tandem repeats – ; Non ; CODIS – ; Genotyping – ; Population data – ; Han population – ; Linkage – ; Linkage Disequilibrium
• 刊名：International Journal of Legal Medicine
• 出版年：2012
• 出版时间：July 2012
• 年：2012
• 卷：126
• 期：4
• 页码：659-664
• 全文大小：133.3 KB
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• 作者单位：1. Shanghai Key Laboratory of Forensic Medicine (Institute of Forensic Science, Ministry of Justice), Shanghai, 200063 PR China2. West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China3. China University of Political Science and Law鈥檚 Key Laboratory of Evidence Science, Ministry of Education, Beijing, 100040 People鈥檚 Republic of China4. Institute of Applied Genetics, University of North Texas, Health Science Center, Fort Worth, TX, USA
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Forensic Medicine
  Medical Law
  Medicine/Public Health, general
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1437-1596

文摘

Allele frequencies and forensic statistics of 21 autosomal short tandem repeat loci (i.e., D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D19S433, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435 and D5S2500) were estimated in Han population from northern China (n = 220). Significant deviation from Hardy–Weinberg equilibrium was detected only for D22S1045. The observed heterozygosity, the expected heterozygosity, the discrimination power, the probability of paternity exclusion in trios, the probability of paternity exclusion in duos and the polymorphic information content ranged from 0.591 to 0.836, 0.594 to 0.830, 0.762 to 0.948, 0.341 to 0.659, 0.189 to 0.487 and 0.535 to 0.807, respectively. Triallelic patterns were observed at D19S433 and D10S1435. Mutations occurred at D22ATA63, D10S1248, D19S433 and D14S1434 loci with all single-step mutations. The expected mutation rates of these four loci are 0.0042 with 95% confidence interval [0.0001, 0.0232] in a total of 238 meioses. Our results show that these 21 non-CODIS STR loci are highly polymorphic and can be useful for human identification and kinship analysis in Northern Han population in China.