Evaluation of diabetic gastroparesis effect of Musa sapientum L. bark juice by reducing the level of oxidative stress

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• 作者：Vaibhav M. Darvhekar (1)
  Alok S. Tripathi (2)
  Shriramji G. Jyotishi (3)
  Papiya Mitra Mazumder (4)
  
• 关键词：Diabeties ; Musa sapientum ; Oxidative stress ; Gastroparesis
• 刊名：Oriental Pharmacy and Experimental Medicine
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：13
• 期：1
• 页码：29-34
• 全文大小：130KB
• 参考文献：1. Baynes JW (1991) Role of oxidative stress in development of complications in diabetes. Diabetes 40:405-12 CrossRef
  2. Beaven K (1999) Gastroparesis and jejunal feeding. J Renal Nutrition 9:202-05 CrossRef
  3. Bittinger M, Barnert J, Wienbeck M (1999) Autonomic dysfunction and the gastrointestinal tract. Clin Auton 9:75-1 CrossRef
  4. Chakravarthy BR, Wang J, Tremblay R, Atkinson TG, Wang F, Li H et al (1998) Comparison of the changes in protein kinase C induced by glutamate in primary cortical neurons and by in vivo cerebral ischaemia. Cell Signal 10:291-95 CrossRef
  5. Chandra D, Jackson EB, Ramana KV, Kelley R, Srivastava SK, Bhatnagar A (2002) Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. Diabetes 51:3095-101 CrossRef
  6. Chandrasekharan B, Anitha M, Blatt R, Shahnavaz N, Kooby D, Staley C, Mwangi S, Jones DP, Sitaraman SV, Srinivasan S (2011) Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress. Neurogastroenterol Motil 23(131-8):e26
  7. Chang KC, Chung SY, Chong WS, Suh JS, Kim SH, Noh HK et al (1993) Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats. J Pharmacol Exp Ther 266:992-000
  8. Dubby JJ, Campbell RK, Setter SM, White JR, Rasmussen KA (2004) Diabetic neuropathy: An intensive review. Amer J Health Sys Pharm 16:160-73
  9. Horowitz M, Fraser R (1994) Disordered gastric motor function in diabetes mellitus. Diabetologia 37:543-51 CrossRef
  10. Kashyap P, Farrugia G (2011) Oxidative stress: Key player in gastrointestinal complications of diabetes. Neurogastroenterol Motil 23(2):111-14 CrossRef
  11. Martin RF, Flynn P (1997) The acute abdomen in the critically ill patient. Surg Clin North Am 77:1455-464 CrossRef
  12. Nilsson PH (1996) Diabetic / gastroparesis: a review./Diabetes Complications. J Diabe Complic 10:113-22 CrossRef
  13. Pereira RV, de Miranda-Neto MH, da Silva Souza ID, Zanoni JN (2008) Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum. J Mol Histol 39:595-03 CrossRef
  14. Perusicova J (2004) Gastrointestinal complications in diabetes mellitus. Vnitr Lek 50:338-43
  15. Rietveld A, Wiseman S (2003) Antioxidant effects of tea: Evidence from human clinical trials. J Nutr 133:3285S-292S
  16. Saxena AK, Srivastava P, Kale RK, Baquer NZ (1993) Impaired antioxidant status in diabeteic rat liver: Effect of vanadate. Biochem Pharmacol 45:539-42 CrossRef
  17. Smirnoff N (ed.) (2005) Antioxidants and reactive oxygen species inplants, Blackwell Publishing Ltd.
  18. Someya S, Yoshiki Y, Okubo K (2002) Antioxidant compounds from bananas ( / Musa Cavendish). Food Chem 79:351-54 CrossRef
  19. Young IS, Tate S, Lightbody JH, McMaster D, Trimble ER (1995) The effects of desferrioxamine and ascorbate on oxidative stress in the streptozotocin diabetic rat. Free Radic Biol Med 18:833-40 CrossRef
  20. Zadák Z, Hy?pler R, Tichá A, Hronek M, Fikrová P, Rathouská J, Hrn?iariková D, ?tětina R (2009) Antioxidants and vitamins in clinical conditions. Physiol Res 58(1):S13–S17
  
• 作者单位：Vaibhav M. Darvhekar (1)
  Alok S. Tripathi (2)
  Shriramji G. Jyotishi (3)
  Papiya Mitra Mazumder (4)
  
  1. Department of Pharmacognosy, P. Wadhwani College of Pharmacy, Yavatmal, MS, India
  2. Department of Pharmacology, P. Wadhwani College of Pharmacy, Yavatmal, MS, India
  3. Shree Ayurvedic College, Hanuman nagar, Nagpur, MS, India
  4. Department of Pharmaceutical sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India
  
• ISSN：2211-1069

文摘

Musa sapientum L. (Musaceae) a medicinal plant, is indicated for the treatment of various diseases including Diabetes in folklore medicine. The purpose of this study is to investigate the effect of Musa sapientum (MS) bark juice in Diabetic gastroparesis and in-vivo antioxidant effect in animal model. Diabetes was induced in rats by administering alloxan (120?mg/kg) in saline solution and housed for 6-?week. Assessment of diabetes was done by GOD-POD method. The effects of MS bark juice (100?ml/kg) on gastric emptying time, intestinal transit time, contractility of fundus, pylorus and gastric acid secretion were observed in alloxan induced chronic diabetic rats. In addition the effect of MS bark juice on the tissue homogenate, oxidative stress parameters was evaluated like Lipid peroxidation (LPO), Superoxide Dismutase (SOD), Catalase (CAT) and Reduced Glutathione (GSH). MS bark juice significantly (p-lt;-.01) Lowered the blood glucose level and at the same time contractility of fundus and pylorus was reduced significantlly (p-lt;-.01). Moreover gastric emptying time, Intestinal transit time and gastric acid secretion were elevated. There was significant decrease in the levels of LPO and increase in the level of antioxidant enzymes GSH, SOD and CAT in MS bark juice treated group. Thus the present study suggests the effect of MS bark juice in treatment of gastroparesis by altering the oxidative stress parameters.