A genetic method to enhance the accumulation of S-adenosylmethionine in yeast
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- 作者：Muneyoshi Kanai ; Masaki Mizunuma ; Tsutomu Fujii…
- 关键词：S ; Adenosylmethionine ; Yeast ; Saccharomyces cerevisiae ; Pichia pastoris ; Sake yeast ; Methionine synthesis pathway
- 刊名：Applied Microbiology and Biotechnology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：101
- 期：4
- 页码：1351-1357
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Microbiology; Microbial Genetics and Genomics; Biotechnology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0614
- 卷排序：101
文摘
S-Adenosylmethionine (SAM) is a key component of sulphur amino acid metabolism in living organisms and is synthesised from methionine and adenosine triphosphate by methionine adenosyltransferase. This molecule serves as the main biological methyl donor due to its active methylthio ether group. Notably, SAM has shown beneficial effects in clinical trials for the treatment of alcoholic liver disease, depression and joint pain. Due to the high potential value of SAM, current research efforts are attempting to develop a more rapid, cost-effective and higher yielding SAM production method than the conventional production system. In this mini-review, we describe the previously reported yeast gene that contributes to SAM accumulation by overexpression, mutation or deletion and summarise the genetic approach for the production of SAM in large industrial quantities.