The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells

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• 作者：S. E. Segerer ; C. Bartmann ; S. Kaspar ; N. Müller…
• 关键词：Cytoskeleton ; Choriocarcinoma ; Proliferation ; Migration
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：293
• 期：2
• 页码：407-414
• 全文大小：1,064 KB
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• 作者单位：S. E. Segerer (1)
  C. Bartmann (2)
  S. Kaspar (3)
  N. Müller (4)
  M. Kapp (2)
  E. Butt (5)
  U. Kämmerer (2)
  
  1. Endokrinologikum Hamburg, Lornsenstraße 4-6, 22767, Hamburg, Germany
  2. Department of Obstetrics and Gynaecology, University of Wuerzburg, Josef-Schneider-Straße 4, 97080, Würzburg, Germany
  3. Clinical Centre of Nuernberg-South, Childrens Hospital, Breslauer Str. 201, 90471, Nuernberg, Germany
  4. Institute for Virology and Immunobiology, University of Wuerzburg, Versbacherstraße 7, 97078, Würzburg, Germany
  5. Institute of Clinical Biochemistry, University of Wuerzburg, Grombuehlstrasse 12, 97080, Würzburg, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Purpose During healthy pregnancy, a distinct but limited invasion of trophoblast cells into the uterus occurs. In contrast, excessive trophoblast invasion is associated with placental choriocarcinoma (CC). Overexpression of the cytoskeletal protein LASP-1 was shown to contribute to cancer aggressiveness. Here, the yet unknown role of LASP-1 in CC cells is analysed.