Microparticle source and tissue factor expression in pregnancy

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• 作者：Amy E. Wong ; Hau C. Kwaan ; William A. Grobman ; Ivy Weiss…
• 关键词：Microparticles ; Pregnancy ; Tissue factor ; Platelets ; Trophoblasts ; Coagulation
• 刊名：Annals of Hematology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：94
• 期：8
• 页码：1285-1290
• 全文大小：139 KB
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• 作者单位：Amy E. Wong (1) (4)
  Hau C. Kwaan (2)
  William A. Grobman (1)
  Ivy Weiss (2)
  Cynthia A. Wong (3)
  
  1. Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
  4. Palo Alto Medical Foundation, 2485 Hospital Drive, Suite 231, Mountain View, CA, 94040, USA
  2. Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
  3. Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Hematology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0584

文摘

Microparticles (MPs) bearing tissue factor (TF) are potent activators of the coagulation system. To investigate whether MPs originating from platelets or trophoblast cells contribute to coagulation changes in pregnancy, we aimed to characterize whether pregnancy, labor, and delivery are associated with changes in the origin and composition of circulating maternal MPs. We performed a prospective cohort study. Blood samples were collected in 20 non-pregnant women, 20 term pregnant women not in labor, and 20 term pregnant women in labor. Two samples were collected in the pregnant groups, the first prior to delivery and the second 1?h after delivery. MPs from platelets and trophoblasts and MPs expressing TF were identified using flow cytometry. Comparisons were made among the non-pregnant and pregnant groups, non-laboring and laboring groups, and predelivery and postdelivery values within the pregnant groups. Pregnancy was not associated with changes in MP origin or number of TF-expressing MPs. Neither labor nor delivery was associated with changes in the percentage of trophoblast-derived MPs in the pregnant groups. The percentage of platelet-derived MPs among laboring women increased after delivery (8.5 vs. 20.5?%, p--.02), although there was no difference with delivery in the non-laboring group. TF expression was not associated with delivery in either laboring or non-laboring women. In conclusion, pregnancy was not associated with changes in cell origin of circulating maternal MPs or in the number of TF-expressing MPs. However, labor and delivery appear to be associated with an increase in the number of platelet-derived MPs.