Mast Cells and Anaphylaxis
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  • 作者：Phil Lieberman ; Lene Heise Garvey
  • 关键词：Anaphylaxis ; Mast cell ; Basophil ; Immunoglobulin E ; Mast cell secretagogues ; MRGPRX2 ; Tryptase ; Mast cell mediators
  • 刊名：Current Allergy and Asthma Reports
  • 出版年：2016
  • 出版时间：March 2016
  • 年：2016
  • 卷：16
  • 期：3
  • 全文大小：915 KB
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  • 作者单位：Phil Lieberman (1) (2)
    Lene Heise Garvey (3)

    1. Divisions of Allergy and Immunology, Departments of Medicine and Pediatrics, University of Tennessee, Memphis, TN, USA
    2. 7205 Wolf River Blvd., Suite 200, Germantown, TN, 38138-1777, USA
    3. Allergy Clinic UA-816, Department of Dermato-allergology, Copenhagen University Hospital, Gentofte, Kildegårdsvej 28, DK-2900, Hellerup, Denmark
  • 刊物主题：Allergology;
  • 出版者：Springer US
  • ISSN：1534-6315
    • 文摘
    For half a century, it has been known that the mast cell is the cell responsible for the majority of anaphylactic events. Its mediators, taken as a whole, are capable of producing all of the clinical manifestations of these events. With the discovery of immunoglobulin E (IgE), it was originally felt that the vast majority of anaphylactic episodes were due to antigen coupling with two cell-bound IgE molecules. More recently it has been learned that many episodes are produced by direct activation of mast cells, not involving antigen binding to IgE, and that monomeric IgE under certain conditions can also cause degranulation. Of note—in regard to antigen independent degranulation—are recent reports that the human G-protein-coupled receptor, MRGPRX2, may be the receptor for many drugs and cationic proteins capable of producing direct mast cell degranulation and anaphylactic events. Keywords Anaphylaxis Mast cell Basophil Immunoglobulin E Mast cell secretagogues MRGPRX2 Tryptase Mast cell mediators

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