Mutant DNMT3A clone evading chemotherapy and infiltrating central nervous system in a patient with molecularly good-risk acute myeloid leukemia

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• 作者：Yi-Yang Chen (1)
  Cih-En Huang (1)
  Hui-Ju Chou (1)
  Pei-Shan Tsai (1)
  Chang-Hsien Lu (1) (4)
  Miao-Fen Chen (3) (4)
  Kuan-Der Lee (1) (4)
  Ping-Tsung Chen (1) (4)
  Jrhau Lung (2)
  Chih-Cheng Chen (1) (4) (5)
  
• 刊名：Annals of Hematology
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：93
• 期：8
• 页码：1441-1442
• 全文大小：850 KB
• 参考文献：1. Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD et al (2012) Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 481(7382):506鈥?10 CrossRef
  2. Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J et al (2010) DNMT3A mutations in acute myeloid leukemia. N Engl J Med 363(25):2424鈥?433 CrossRef
  3. Marcucci G, Metzeler KH, Schwind S, Becker H, Maharry K, Mrozek K, Radmacher MD, Kohlschmidt J, Nicolet D, Whitman SP et al (2012) Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol 30(7):742鈥?50 CrossRef
  4. Renneville A, Boissel N, Nibourel O, Berthon C, Helevaut N, Gardin C, Cayuela JM, Hayette S, Reman O, Contentin N et al (2012) Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association. Leukemia 26(6):1247鈥?254 CrossRef
  5. Ribeiro AF, Pratcorona M, Erpelinck-Verschueren C, Rockova V, Sanders M, Abbas S, Figueroa ME, Zeilemaker A, Melnick A, Lowenberg B et al (2012) Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood 119(24):5824鈥?831 CrossRef
  6. Gaidzik VI, Schlenk RF, Paschka P, Stolzle A, Spath D, Kuendgen A, von Lilienfeld-Toal M, Brugger W, Derigs HG, Kremers S et al (2013) Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG). Blood 2013
  7. Abdel-Wahab O, Levine RL (2013) Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood 121(18):3563鈥?572 CrossRef
  8. Patel JP, Gonen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, Van Vlierberghe P, Dolgalev I, Thomas S, Aminova O et al (2012) Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 366(12):1079鈥?089 CrossRef
  
• 作者单位：Yi-Yang Chen (1)
  Cih-En Huang (1)
  Hui-Ju Chou (1)
  Pei-Shan Tsai (1)
  Chang-Hsien Lu (1) (4)
  Miao-Fen Chen (3) (4)
  Kuan-Der Lee (1) (4)
  Ping-Tsung Chen (1) (4)
  Jrhau Lung (2)
  Chih-Cheng Chen (1) (4) (5)
  
  1. Division of Hematology and Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan
  4. Graduate Institute of Clinical Medical Sciences, Chang Gung University, Tao-Yuan, Taiwan
  3. Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan
  2. Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan
  5. Department of Medicine, Chang Gung Memorial Hospital, Chiayi, No. 6, Sec. West, Chia-Pu Road, Pu-Tz City, Chiayi County, 613, Taiwan
  
• ISSN：1432-0584

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