Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyp
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- 作者：Rong-Jyh Lin (1)
Chuan-Min Yen (1)
Tzung-Han Chou (2)
Feng-Yu Chiang (3)
Guey-Horng Wang (4)
Ya-Ping Tseng (5)
Lin Wang (6)
Ting-Wei Huang (7)
Hui-Chuan Wang (8)
Leong-Perng Chan (3) (9)
Hsiou-Yu Ding (8)
Chia-Hua Liang (4) - 关键词：Yakuchinone A ; Antioxidant ; Adipogenesis ; Apoptosis ; Hymenolepis nana ; Anisakis simplex
- 刊名：BMC Complementary and Alternative Medicine
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：13
- 期：1
- 全文大小：1,733 KB
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41. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/13/237/prepub - 作者单位：Rong-Jyh Lin (1)
Chuan-Min Yen (1)
Tzung-Han Chou (2)
Feng-Yu Chiang (3)
Guey-Horng Wang (4)
Ya-Ping Tseng (5)
Lin Wang (6)
Ting-Wei Huang (7)
Hui-Chuan Wang (8)
Leong-Perng Chan (3) (9)
Hsiou-Yu Ding (8)
Chia-Hua Liang (4)
1. Department of Parasitology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
2. Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin, Taiwan
3. Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
4. Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
5. Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
6. Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
7. Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
8. Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
9. Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan - ISSN：1472-6882
文摘
Background Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities. Methods Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as well as novel mechanisms for the inhibition of adipocyte differentiation, cestocidal activities against Hymenolepis nana adults, and nematocidal activities against Anisakis simplex larvae are investigated. Results Yakuchinone A presents the ability of the removal of DPPH·and ABTS+ free radicals and inhibition of lipid peroxidation. Yakuchinone A suppresses intracellular lipid accumulation during adipocyte differentiation in 3?T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor γ (PPARγ). Yakuchinone A induces apoptosis and inhibits cell proliferation in skin cancer cells. The inhibition of cell growth by yakuchinone A is more significant for non-melanoma skin cancer (NMSC) cells than for melanoma (A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells with yakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and an increase in cleavage poly (ADP-ribose) polymerase (PARP). This suggests that yakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signaling pathway. The anthelmintic activities of yakuchinone A for A. simplex are better than for H. nana. Conclusions In this work, yakuchinone A exhibits antioxidative properties, anti-adipocyte differentiation, antitumor activity, and anthelmintic activities against A. simplex and H. nana.