Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters
详细信息 查看全文
- 作者：Jia-Ping Wu ; Cheng-Hong Hsieh ; Tsung-Jung Ho ; Wei-Wen Kuo…
- 关键词：Left ventricular hypertrophy ; Secondhand smoke exposure ; Aging ; Pro ; inflammatory response ; Aged SHS exposure
- 刊名：BMC Cardiovascular Disorders
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：14
- 期：1
- 全文大小：1,515 KB
- 参考文献：1. Hoegg, UR (1972) Cigarette smoke in closed spaces. Environ Health Perspect 2: pp. 117-128 target="_blank" title="It opens in new window">CrossRef
2. Tong, EK, Glantz, SA (2007) Tobacco industry efforts undermining evidence linking secondhand smoke with cardiovascular disease. Circulation 116: pp. 1845-1854 target="_blank" title="It opens in new window">CrossRef
3. Bard, RL, Dvonch, JT, Kaciroti, N, Lustig, SA, Brook, RD (2010) Is acute high-dose secondhand smoke exposure always harmful to microvascular function in healthy adults?. Prev Cardiol 13: pp. 175-179 target="_blank" title="It opens in new window">CrossRef
4. Weeks, SG, Glantz, SA, De Marco, T, Rosen, AB, Fleischmann, KE (2011) Secondhand smoke exposure and quality of life in patients with heart failure. Arch Intern Med 171: pp. 1887-1893 target="_blank" title="It opens in new window">CrossRef
5. Slayton, RL (2012) Exposure to secondhand smoke may cause dental caries in children. J Evid Based Dent Pract 12: pp. 8-9 target="_blank" title="It opens in new window">CrossRef
6. Heiss, C, Amabile, N, Lee, AC, Real, WM, Schick, SF, Lao, D (2008) Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol 51: pp. 1760-1771 target="_blank" title="It opens in new window">CrossRef
7. Dai, DF, Chen, T, Johnson, SC, Szeto, H, Rabinovitch, PS (2012) Cardiac aging: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal 16: pp. 1492-1526 target="_blank" title="It opens in new window">CrossRef
8. Whittington, HJ, Harding, I, Stephenson, CI, Bell, R, Hausenloy, DJ, Mocanu, MM, Yellon, DM (2013) Cardio protection in the aging, diabetic heart: the loss of protective Akt signaling. Cardiovasc Res 99: pp. 694-704 target="_blank" title="It opens in new window">CrossRef
9. Waller, BF (1988) The old-age heart: normal aging changes which can produce or mimic cardiac disease. Clin Cardiol 11: pp. 513-517 target="_blank" title="It opens in new window">CrossRef
10. Sugiura, M (1994) Characteristic features of the heart disease in the elderly. Nihon Ronen Igakkai Zasshi 31: pp. 182-186 target="_blank" title="It opens in new window">CrossRef
11. Hacker, TA, McKiernan, SH, Douglas, PS, Wanagat, J, Aiken, JM (2006) Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats. Am J Physiol Heart Circ Physiol 290: pp. H304-H311 target="_blank" title="It opens in new window">CrossRef
12. Nadal-Ginard, B, Kajstura, J, Leri, A, Anversa, P (2003) Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res 92: pp. 139-150 target="_blank" title="It opens in new window">CrossRef
13. Juonala, M, Magnussen, CG, Venn, A, Gall, S, K?h?nen, M, Laitinen, T (2012) Parental smoking in childhood and brachial artery flow-mediated dilatation in young adults: the cardiovascular risk in young Finns study and the childhood determinants of adult health study. Arterioscler Thromb Vasc Biol 32: pp. 1024-1031 target="_blank" title="It opens in new window">CrossRef
14. Martin Rdos, S, Martin, LC, Franco, RJ, Barretti, P, Caramori, JC, Castro, JH (2012) Ventricular hypertrophy and cardiovascular mortality in hemodialysis patients with low educational level. Arq Bras Cardiol 98: pp. 52-61 target="_blank" title="It opens in new window">CrossRef
15. van Eps, CL, Jeffriess, L, Haluska, B, Hawley, CM, Coombes, J (2011) Cardiac and vascular structure and function parameters do not improve with alternate nightly home hemodialysis: an interventional cohort study. BMC Nephrol 12: pp. 51 target="_blank" title="It opens in new window">CrossRef
16. Olivetti, G, Melissari, M, Capasso, JM, Anversa, P (199 - 刊物主题：Cardiology; Cardiac Surgery; Angiology; Blood Transfusion Medicine; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2261
文摘
Background Aging is associated with physiological or pathological left ventricular hypertrophy (LVH) cardiac changes. Secondhand smoke (SHS) exposure is associated with pathological LVH. The action mechanism in cardiac concentric hypertrophy from SHS exposure is understood, but the transition contributed from SHS exposure is not. To determine whether exposure to SHS has an impact on age-induced LVH we examined young and old hamsters that underwent SHS exposure in a chamber for 30 mins. Methods Morphological and histological studies were then conducted using hematoxylin and eosin (H&E) and Masson’s trichrome staining. Echocardiographic analysis was used to determine left ventricular wall thickness and function. LVH related protein expression levels were detected by western blot analysis. Results The results showed that both young and aged hamsters exposed to SHS exhibited increased heart weights and left ventricular weights, left ventricular posterior wall thickness and intraventricular septum systolic and diastolic pressure also increased. However, left ventricular function systolic and diastolic pressure deteriorated. H&E and Masson’s trichrome staining results showed LV papillary muscles were ruptured, resulting in lower cardiac function at the myocardial level. LV muscle fiber arrangement was disordered and collagen accumulation occurred. Concentric LVH related protein molecular markers increased only in young hamsters exposed to SHS. However, this declined with hamster age. By contrast, eccentric LVH related proteins increased in aging hamsters exposed the SHS. Pro-inflammatory proteins, IL-6, TNF-α, JAK1, STAT3, and SIRTI expression increased in aging hamsters exposed to SHS. Conclusions We suggest that SHS exposure induces a pro-inflammatory response that results in concentric transition to aging eccentric LVH.