Efficacy of vitamin D₃ supplementation in reducing incidence of pulmonary tuberculosis and mortality among HIV-infected Tanzanian adults initiating antiretroviral therapy: study protocol for a randomized controlled trial

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• 作者：Christopher R. Sudfeld ; Ferdinand Mugusi ; Said Aboud ; Tumaini J. Nagu ; Molin Wang…
• 关键词：HIV ; Tuberculosis ; Vitamin D ; Micronutrient ; Cholecalciferol ; Nutrition ; Tanzania
• 刊名：Trials
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：786KB
• 刊物主题：Medicine/Public Health, general; Biomedicine, general; Statistics for Life Sciences, Medicine, Health Sciences;
• 出版者：BioMed Central
• ISSN：1745-6215
• 卷排序：18

文摘

BackgroundHIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the initial months of treatment. Observational studies in high-income and resource-limited settings indicate that HIV-infected adults with low vitamin D levels may be at increased risk of mortality, HIV disease progression, and incidence of pulmonary tuberculosis (TB). As a result, vitamin D₃ supplementation may improve survival and treatment outcomes for HIV-infected adults initiating ART.