Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System
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- 作者：Chen-Hsi Hsieh ; Mei-Ling Hou ; Li-Ying Wang ; Hung-Chi Tai ; Tung-Hu Tsai…
- 关键词：5 ; Fluorouracil (5 ; FU) ; Lymphatic ; Pharmacokinetics ; Radiotherapy ; Rectal cancer
- 刊名：BMC Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：638 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background 5-fluorouracil (5-FU) is employed to enhance radiotherapy (RT) effect. Here, we evaluated the influence of whole-pelvic irradiation on the pharmacokinetics (PK) of 5-FU in plasma and lymphatic system of rats as the experimental model.