Whole pelvic helical tomotherapy for locally advanced cervical cancer: technical implementation of IMRT with helical tomothearapy

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• 作者：Chen-Hsi Hsieh (1) (3)
  Ming-Chow Wei (2)
  Hsing-Yi Lee (1)
  Sheng-Mou Hsiao (2)
  Chien-An Chen (1)
  Li-Ying Wang (7)
  Yen-Ping Hsieh (8)
  Tung-Hu Tsai (3) (9)
  Yu-Jen Chen (3) (4) (5) (6)
  Pei-Wei Shueng (1) (10) (11)
  
• 刊名：Radiation Oncology
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：4
• 期：1
• 全文大小：419KB
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• 作者单位：Chen-Hsi Hsieh (1) (3)
  Ming-Chow Wei (2)
  Hsing-Yi Lee (1)
  Sheng-Mou Hsiao (2)
  Chien-An Chen (1)
  Li-Ying Wang (7)
  Yen-Ping Hsieh (8)
  Tung-Hu Tsai (3) (9)
  Yu-Jen Chen (3) (4) (5) (6)
  Pei-Wei Shueng (1) (10) (11)
  
  1. Department of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan
  3. Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  2. Departments of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Taipei, Taiwan
  7. School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan
  8. Department of Healthcare Administration, Asia University, Taichung, Taiwan
  9. Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
  4. Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan
  5. Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
  6. Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan
  10. Department of Radiation Oncology, National Defense Medical Center, Taipei, Taiwan
  11. General Education Center, Oriental Technology Institute, Taipei, Taiwan
  

文摘

Background To review the experience and to evaluate the treatment plan of using helical tomotherapy (HT) for the treatment of cervical cancer. Methods Between November 1st, 2006 and May 31, 2009, 10 cervical cancer patients histologically confirmed were enrolled. All of the patients received definitive concurrent chemoradiation (CCRT) with whole pelvic HT (WPHT) followed by brachytherapy. During WPHT, all patients were treated with cisplatin, 40 mg/m2 intravenously weekly. Toxicity of treatment was scored according to the Common Terminology Criteria for Adverse Events v3.0 (CTCAE v3.0). Results The mean survival was 25 months (range, 3 to 27 months). The actuarial overall survival, disease-free survival, locoregional control and distant metastasis-free rates at 2 years were 67%, 77%, 90% and 88%, respectively. The average of uniformity index and conformal index was 1.06 and 1.19, respectively. One grade 3 of acute toxicity for diarrhea, thrombocytopenia and three grade 3 leucopenia were noted during CCRT. Only one grade 3 of subacute toxicity for thrombocytopenia was noted. There were no grade 3 or 4 subacute toxicities of anemia, leucopenia, genitourinary or gastrointestinal effects. Compared with conventional whole pelvic radiation therapy (WPRT), WPHT decreases the mean dose to rectum, bladder and intestines successfully. Conclusion HT provides feasible clinical outcomes in locally advanced cervical cancer patients. Long-term follow-up and enroll more locally advanced cervical carcinoma patients by limiting bone marrow radiation dose with WPHT technique is warranted.