Synthesis and characterization of poly (N-isopropylacrylamide)-g-carboxymethyl chitosan copolymer-based doxorubicin-loaded polymeric nanoparticles for thermoresponsive drug release

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• 作者：M. Gover Antoniraj ; C. Senthil Kumar ; Ruckmani Kandasamy
• 关键词：Poly (N ; isopropylacrylamide) ; O ; carboxymethyl chitosan ; Polymer synthesis ; Smart polymers ; Thermal properties
• 刊名：Colloid & Polymer Science
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：294
• 期：3
• 页码：527-535
• 全文大小：909 KB
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• 作者单位：M. Gover Antoniraj (1)
  C. Senthil Kumar (1)
  Ruckmani Kandasamy (1) (2)
  
  1. Centre for Excellence in Nanobio Translational Research (CENTRE), Department of Pharmaceutical Technology, Anna University, BIT campus, Tiruchirappalli, 620024, Tamilnadu, India
  2. National Facility for Drug Development for cademia, Pharmaceutical and Allied Industries (NFDD), Anna University, BIT campus, Tiruchirappalli, 620024, Tamilnadu, India
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Physical Chemistry
  Soft Matter and Complex Fluids
  Characterization and Evaluation Materials
  Food Science
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-1536

文摘

Thermoresponsive graft copolymer (PNIPAm-g-OCMC) with PNIPAm and chitosan was prepared by conjugation of amine-terminated PNIPAm with O-carboxymethylchitosan through graft-onto method. The results of FTIR and proton NMR confirmed the synthesis of a copolymer. Furthermore, XRD analysis revealed conjugation reaction of polymeric materials. Doxorubicin-loaded polymeric nanoparticles (D-PNPs) were fabricated using copolymer by gelation method. Morphology illustration through TEM showed the spherical shape of D-PNPs. Particles size measurement study indicates thermoresponsive properties of D-PNPs at various temperatures. Lower critical solution temperature (LCST) of D-PNPs was obtained at 38 °C predicted by turbidimetry analysis. Release studies at three different temperatures notified that thermoresponsive doxorubicin release of D-PNPs. The release of doxorubicin was slower at 25 °C, moderately released at 37 °C, and faster released at 42 °C due to adjustment of the framework of the D-PNPs. Based on the results such as transmittance measurement, particle size observation, and release studies, we declare that the D-PNPs exhibit temperature-responsive behavior, which could make them appropriate for a thermoresponsive drug delivery.