Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene
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- 作者：Hongyu Ying ; Sanja Turturro ; Tara Nguyen ; Xiang Shen ; Ruth Zelkha…
- 关键词：Optineurin ; Glaucoma ; Amyotrophic lateral sclerosis ; Ubiquitin ; proteasome pathway (UPP) ; Autophagy ; Adeno ; associated type 2 viral (AAV2) vectors ; E50K mutation ; Rat
- 刊名：BMC Cell Biology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：1,951 KB
- 刊物主题：Cell Biology; Biological Microscopy; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2121
文摘
Background Optineurin is a gene associated with normal tension glaucoma and amyotrophic lateral sclerosis. It has been reported previously that in cultured RGC5 cells, the turnover of endogenous optineurin involves mainly the ubiquitin-proteasome pathway (UPP). When optineurin is upregulated or mutated, the UPP function is compromised as evidenced by a decreased proteasome β5 subunit (PSMB5) level and autophagy is induced for clearance of the optineurin protein.