Extracellular heat shock proteins protect U937 cells from H2O2-induced apoptotic cell death
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- 作者：Lourdes Franco ; Jorge Terrinca ; Ana B. Rodríguez…
- 关键词：Heat shock proteins ; Cell viability ; Caspase ; H2O2 ; U937 cells
- 刊名：Molecular and Cellular Biochemistry
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：412
- 期：1-2
- 页码：19-26
- 全文大小：760 KB
- 参考文献：1.Garrido C, Gurbuxani S, Ravagnan L, Kroemer G (2001) Heat shock proteins: endogenous modulators of apoptotic cell death. Biochem Biophys Res Commun 286:433–442PubMed CrossRef
2.Morimoto RI (1998) Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12:3788–3796PubMed CrossRef
3.Parceiller A, Gurbuxani S, Schmitt E, Solary E, Garrido C (2003) Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun 304:505–512CrossRef
4.Stennicke HT, Salvesen GS (1997) Biochemical characteristics of caspase-3, -6, -7, and -8. J Biol Chem 272:25719–25723PubMed CrossRef
5.Lanneau D, Brunet M, Frisan E, Solary E, Fontenay M, Garrido C (2008) Heat shock proteins: essential proteins for apoptosis regulation. J Cell Mol Med 12:1–19CrossRef
6.Mjahed H, Girondon F, Fontenay M, Garrido C (2012) Heat shock proteins in hematopoietic malignancies. Exp Cell Res 318:1946–1958PubMed CrossRef
7.Jego G, Hazoume R, Seigneuric C, Garrido C (2013) Targeting heat shock proteins in cancer. Cancer Lett 332:275–285PubMed CrossRef
8.Kennedy D, Jäger R, Mosser DD, Samali A (2014) Regulation of apoptosis by heat shock proteins. IUBMB Life 65:327–338CrossRef
9.Garrido C, Bruey JM, Fromentin A, Hammann A, Arrigo AP, Solary E (1999) HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J 13:2061–2070PubMed
10.Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G (2006) Heat shock proteins 27 and 70: antiapoptotic proteins with tumorigenic properties. Cell Cycle 5:2592–2601PubMed CrossRef
11.Mosser DD, Morimoto RI (2004) Molecular chaperones and the stress of oncogenesis. Oncogene 23:2907–2918PubMed CrossRef
12.Aghdassi A, Phillips P, Dudeja V, Dhaulakhandi D, Sharif R, Dawra R, Lerch MM, Saluja A (2007) Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma. Cancer Res 67:616–625PubMed CrossRef
13.Choi DH, Ha JS, Lee WH, Song JK, Kim GY, Park JH, Cha HJ, Lee BJ, Park JW (2007) Heat shock protein 27 is associated with irinotecan resistance in human colorectal cancer cells. FEBS Lett 581:1649–1656PubMed CrossRef
14.Luo X, Tao L, Lin P, Mo X, Chen H (2012) Extracellular heat shock protein 72 protects Schwann cells from hydrogen peroxide-induced apoptosis. J Neurosci Res 90:1261–1269PubMed CrossRef
15.Taylor AR, Robinson MB, Gifondorwa DJ, Tytell M, Milligan CE (2007) Regulation of heat shock protein 70 release in astrocytes: role of signaling kinase. Dev Neurobiol 67:1815–1829PubMed CrossRef
16.Bejarano I, Espino J, Marchena AM, Barriga C, Paredes SD, Rodríguez AB, Pariente JA (2011) Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem 353:167–176PubMed CrossRef
17.Bejarano I, Redondo PC, Espino J, Rosado JA, Paredes SD, Barriga C, Reiter RJ, Pariente JA, Rodríguez AB (2009) Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells. J Pineal Res 46:392–400PubMed CrossRef
18.Espino J, Bejarano I, Paredes SD, Barriga C, Reiter RJ, Pariente JA, Rodríguez AB (2011) Melatonin is able to delay endoplasmic reticulum stress-induced apoptosis in leukocytes from elderly humans. Age 33:497–507PubMed PubMedCentral CrossRef
19.Espino J, Bejarano I, Paredes SD, Barriga C, Rodríguez AB, Pariente JA (2011) Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions. J Pineal Res 51:195–206PubMed CrossRef
20.Samali A, Orrenius S (1998) Heat shock proteins: regulators of stress response and apoptosis. Cell Stress Chaperones 3:228–236PubMed PubMedCentral CrossRef
21.Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK (2002) Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277:15028–15034PubMed CrossRef
22.Vabulas RM, Ahmad-Nejad P, Ghose S, Kirchning CJ, Issel RD, Wagner H (2002) HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 277:15107–15112PubMed CrossRef
23.Svensson PA, Asea A, Englund MC, Bausero MA, Jernas M, Wiklund O, Ohlsson BG, Carlsson LM, Carlsson B (2006) Major role of HSP70 as a paracrine inducer of cytokine production in human oxidized LDL treated macrophages. Atherosclerosis 185:32–38PubMed PubMedCentral CrossRef
24.Tidwell JL, Houenou LJ, Tytell M (2004) Administration of HSP70 in vivo inhibits motor and sensory neuron degeneration. Cell Stress Chaperones 9:88–98PubMed PubMedCentral CrossRef
25.Guzhova I, Kislyakova K, Moskaliova O, Fridlanskaya I, Tytell M, Cheetham M, Margulis B (2001) In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res 914:66–73PubMed CrossRef
26.Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS (2004) Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol 287:817–833CrossRef
27.Kahya MC, Naziroglu M, Cig B (2014) Seleium reduces mobile phone (900 MHz)-induced oxidative stress, mitochondrial function, and apoptosis in breast cancer cells. Bio Trace Elem Res 160:285–293CrossRef
28.Naziroglu MC, Tokat S, Demirci S (2012) Role of melatonin on electromagnetic radiation-induced oxidative stress and Ca2+ signaling molecular pathways in breast cancer. J Recept Signal Transduct Res 36:290–297CrossRef
29.Barbouti A, Doulias PT, Nousis L, Tenopoulou M, Galaris D (2002) DNA damage and apoptosis in hydrogen peroxide-exposed Jurkat cells: bolus addition vs. Continuous generation of H2O2. Free Radic Biol Med 33:691–702PubMed CrossRef
30.Yu Y, Liu M, Zhang L, Cao Q, Zhang P, Jiang H, Zou Y, Ge J (2012) Heat shock transcription factor 1 inhibits H2O2-induced cardiomyocyte death through suppression of high-mobility group 1. Mol Cell Biochem 364:263–269PubMed CrossRef
31.Kiang JG, Ding XZ, McClain DE (1996) Thermotolerance attenuates heat-induced increases in [Ca2+]i and HSP-72 synthesis but not heat-induced intracellular acidification in human A-431 cells. J Investig Med 44:53–63PubMed - 作者单位：Lourdes Franco (1)
Jorge Terrinca (1)
Ana B. Rodríguez (1)
Javier Espino (1)
José A. Pariente (1)
1. Department of Physiology, Neuroimmunophysiology and Chrononutrition Research Group, Faculty of Science, University of Extremadura, Avda. de Elvas s/n, 06006, Badajoz, Spain - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Biochemistry
Medical Biochemistry
Oncology
Cardiology - 出版者：Springer Netherlands
- ISSN：1573-4919
文摘
The cytoprotective role of heat shock proteins (HSPs) has been demonstrated in various cell types however, only few studies have investigated the role of extracellular exposure to HSPs in the survival of human lymphoma cell line U937. In the present study, we investigated the effect of extracellular exposure to four HSPs (HSP90, HSP70, HSP60, and HSP47) on apoptotic cell death induced by either oxidative stress (hydrogen peroxide) or endoplasmic reticulum stress-mediated intracellular calcium overload. It was found that extracellular exposure to HSPs reduced the cytotoxicity induced by hydrogen peroxide, but not that evoked by thapsigargin (a specific inhibitor of cytosolic calcium reuptake which is able to induce endoplasmic reticulum stress with subsequent intracellular calcium overload). Similarly, it was observed that exogenous HSPs were able to suppress the caspase-3 activation induced by hydrogen peroxide. These findings indicate that extracellular HSPs increase the resistance of human lymphoma cell line U937 to apoptotic cell death induced by hydrogen peroxide and diminish oxidative stress-mediated injures. Keywords Heat shock proteins Cell viability Caspase H2O2 U937 cells