Respiratory Complex I: Structure, Redox Components, and Possible Mechanisms of Energy Transduction

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• 作者：A. D. Vinogradov
• 关键词：NADH ; quinone oxidoreductase ; Complex I ; respiratory chain ; proton translocation ; electrochemical coupling
• 刊名：Biochemistry (Moscow)
• 出版年：2001
• 出版时间：2001
• 年：2001
• 卷：66
• 期：10
• 页码：1086-1097
• 全文大小：937 KB

文摘

Structural arrangements and properties of redox components of the mitochondrial and bacterial proton-translocating NADH:quinone oxidoreductases are briefly described. A model for the mechanism of proton translocation at first coupling site, which emphasizes participation of specifically Complex I-associated ubisemiquinones, is discussed. An alternative mechanism is proposed where all redox reactions take place in a hydrophilic part of the enzyme and the free energy accumulated as conformational constraint drives the proton pump associated with the hydrophobic polypeptides.