1H-MRS and MEGA-PRESS pulse sequence in the study of balance of inhibitory and excitatory neurotransmitters in the human brain of ultra-high risk of schizophrenia patients

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• 作者：P. E. Menschikov ; N. A. Semenova ; M. V. Ublinskiy…
• 刊名：Doklady Biochemistry and Biophysics
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：468
• 期：1
• 页码：168-172
• 全文大小：557 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Biophysics and Biomedical Physics
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3091
• 卷排序：468

文摘

The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the 1H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.Original Russian Text © P.E. Menschikov, N.A. Semenova, M.V. Ublinskiy, T.A. Akhadov, R.A. Keshishyan, I.S. Lebedeva, M.A. Omelchenko, V.G. Kaleda, S.D. Varfolomeev, 2016, published in Doklady Akademii Nauk, 2016, Vol. 468, No. 1, pp. 103–107.