An evaluation of the sonoporation potential of low-boiling point phase-change ultrasound contrast agents in vitro
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- 作者：Samantha M. Fix ; Anthony Novell ; Yeoheung Yun…
- 关键词：Sonoporation ; Ultrasound ; Drug delivery ; Acoustic droplet vaporization ; Nanodroplet
- 刊名：Journal of Therapeutic Ultrasound
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：5
- 期：1
- 全文大小：1530KB
- 刊物主题：Ultrasound; Imaging / Radiology;
- 出版者：BioMed Central
- ISSN：2050-5736
- 卷排序：5
文摘
BackgroundPhase-change ultrasound contrast agents (PCCAs) offer a solution to the inherent limitations associated with using microbubbles for sonoporation; they are characterized by prolonged circulation lifetimes, and their nanometer-scale sizes may allow for passive accumulation in solid tumors. As a first step towards the goal of extravascular cell permeabilization, we aim to characterize the sonoporation potential of a low-boiling point formulation of PCCAs in vitro.