Prevention of lung injury by Muc1 mucin in a mouse model of repetitive Pseudomonas aeruginosa infection

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• 作者：Tsuyoshi Umehara (13)
  Kosuke Kato (1)
  Yong Sung Park (1)
  Erik P. Lillehoj (2)
  Hideyuki Kawauchi (3)
  Kwang Chul Kim (14) kckim@temple.edu
• 关键词：Respiratory – ; MUC1 mucin – ; Pseudomonas aeruginosa – ; Inflammation – ; Airspace enlargement
• 刊名：Inflammation Research
• 出版年：2012
• 出版时间：September 2012
• 年：2012
• 卷：61
• 期：9
• 页码：1013-1020
• 全文大小：474.7 KB
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• 作者单位：1. Center for Inflammation, Translational and Clinical Lung Research, Temple University School of Medicine, Philadelphia, PA, USA2. Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA3. Department of Otorhinolaryngology, Faculty of Medicine, Shimane University, Izumo, Japan4. Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
• ISSN：1420-908X

文摘

Objective and design To determine whether repetitive airway Pseudomonas aeruginosa (Pa) infection results in lung inflammation and injury and, if so, whether these responses are affected by Muc1 mucin. Muc1 wild type (WT) and knockout (KO) mice were compared for body weights, lung inflammatory responses, and airspace enlargement using a chronic lung infection model system.