Association between osteocalcin and metabolic syndrome in postmenopausal women

详细信息    查看全文

• 作者：Suk Woo Lee ; Hyun Hee Jo ; Mee Ran Kim…
• 关键词：Adipokine ; Insulin resistance ; Metabolic syndrome ; Osteocalcin ; Postmenopause
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：292
• 期：3
• 页码：673-681
• 全文大小：390 KB
• 参考文献：1.Isleten B, Durmaz B, Durmaz B, Onay H, Ozkinay F, Durmaz A, Turan V, Oztekin K (2013) The association of RANK gene C421T and C575T polymorphism with bone mineral density in postmenopausal Turkish women. Arch Gynecol Obstet 288(4):917鈥?23PubMed View Article
  2.Eckel RH, Grundy SM, Zimmet PZ (2005) The metabolic syndrome. Lancet 365(9468):1415鈥?428PubMed View Article
  3.Davis SR, Castelo-Branco C, Chedraui P, Lumsden MA, Nappi RE, Shah D, Villaseca P (2012) Understanding weight gain at menopause. Climacteric 15(5):419鈥?29PubMed View Article
  4.Ritland LM, Alekel DL, Matvienko OA, Hanson KB, Stewart JW, Hanson LN, Reddy MB, Van Loan MD, Genschel U (2008) Centrally located body fat is related to appetitive hormones in healthy postmenopausal women. Eur J Endocrinol 158(6):889鈥?97PubMed Central PubMed View Article
  5.Wellen KE, Hotamisligil GS (2003) Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112(12):1785鈥?788PubMed Central PubMed View Article
  6.Cao JJ (2011) Effects of obesity on bone metabolism. J Orthop Surg Res 6:30PubMed Central PubMed View Article
  7.Kang AR, Oh YR, Kim HY, Park MJ, Joo BS, Choi WJ, Jung MH, Ji YI, Choi JS (2012) Up-regulation of inhibitors of DNA binding/differentiation gene during alendronate-induced osteoblast differentiation. Arch Gynecol Obstet 285(5):1331鈥?338PubMed Central PubMed View Article
  8.Hauschka PV, Lian JB, Cole DE, Gundberg CM (1989) Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev 69(3):990鈥?047PubMed
  9.Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130(3):456鈥?69PubMed Central PubMed View Article
  10.Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers MG Jr, Chua SC Jr, Kim JK, Kaestner KH, Karsenty G (2008) The sympathetic tone mediates leptin鈥檚 inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol 183(7):1235鈥?242PubMed Central PubMed View Article
  11.Clemens TL, Karsenty G (2011) The osteoblast: an insulin target cell controlling glucose homeostasis. J Bone Miner Res 26(4):677鈥?80PubMed View Article
  12.Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15(7):539鈥?53PubMed View Article
  13.Wolf G (1996) Function of the bone protein osteocalcin: definitive evidence. Nutr Rev 54(10):332鈥?33PubMed View Article
  14.Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G (1996) Increased bone formation in osteocalcin-deficient mice. Nature 382(6590):448鈥?52PubMed View Article
  15.Neve A, Corrado A, Cantatore FP (2013) Osteocalcin: skeletal and extra-skeletal effects. J Cell Physiol 228(6):1149鈥?153PubMed View Article
  16.Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G (2010) Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142(2):296鈥?08PubMed Central PubMed View Article
  17.Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Bruning JC, Clemens TL (2010) Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142(2):309鈥?19PubMed Central PubMed View Article
  18.Ducy P (2011) The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism. Diabetologia 54(6):1291鈥?297PubMed View Article
  19.Bae SJ, Choe JW, Chung YE, Kim BJ, Lee SH, Kim HY, Koh JM, Kim HK, Kim GS (2011) The association between serum osteocalcin levels and metabolic syndrome in Koreans. Osteoporos Int 22(11):2837鈥?846PubMed View Article
  20.Yang R, Ma X, Pan X, Wang F, Luo Y, Gu C, Bao Y, Jia W (2013) Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women. Menopause 20(5):548鈥?53PubMed
  21.Liu JJ, Toy WC, Wong MD, Tan CS, Tavintharan S, Wong MS, Sum CF, Lim SC (2013) Elevated undercarboxylated and reduced carboxylated osteocalcin are associated with metabolic syndrome in middle age Asian females. Exp Clin Endocrinol Diabetes 121(6):329鈥?33PubMed View Article
  22.Saleem U, Mosley TH Jr, Kullo IJ (2010) Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol 30(7):1474鈥?478PubMed Central PubMed View Article
  23.Lu C, Ivaska KK, Alen M, Wang Q, Tormakangas T, Xu L, Wiklund P, Mikkola TM, Pekkala S, Tian H, Vaananen HK, Cheng S (2012) Serum osteocalcin is not associated with glucose but is inversely associated with leptin across generations of nondiabetic women. J Clin Endocrinol Metab 97(11):4106鈥?114PubMed View Article
  24.Chen L, Li Q, Yang Z, Ye Z, Huang Y, He M, Wen J, Wang X, Lu B, Hu J, Liu C, Ling C, Qu S, Hu R (2013) Osteocalcin, glucose metabolism, lipid profile and chronic low-grade inflammation in middle-aged and elderly Chinese. Diabet Med 30(3):309鈥?17PubMed View Article
  25.Movahed A, Larijani B, Nabipour I, Kalantarhormozi M, Asadipooya K, Vahdat K, Akbarzadeh S, Farrokhnia M, Assadi M, Amirinejad R, Bargahi A, Sanjdideh Z (2012) Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism. J Bone Miner Metab 30(6):683鈥?91PubMed View Article
  26.Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S, Sugimoto T (2011) Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int 22(1):187鈥?94PubMed View Article
  27.Usui C, Asaka M, Kawano H, Aoyama T, Ishijima T, Sakamoto S, Higuchi M (2010) Visceral fat is a strong predictor of insulin resistance regardless of cardiorespiratory fitness in non-diabetic people. J Nutr Sci Vitaminol (Tokyo) 56(2):109鈥?16View Article
  28.Hanley AJ, Karter AJ, Festa A, D鈥橝gostino R Jr, Wagenknecht LE, Savage P, Tracy RP, Saad MF, Haffner S (2002) Factor analysis of metabolic syndrome using directly measured insulin sensitivity: the Insulin Resistance Atherosclerosis Study. Diabetes 51(8):2642鈥?647PubMed View Article
  29.Czernichow S, Kengne AP, Huxley RR, Batty GD, de Galan B, Grobbee D, Pillai A, Zoungas S, Marre M, Woodward M, Neal B, Chalmers J (2011) Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. Eur J Cardiovasc Prev Rehabil 18(2):312鈥?19PubMed Central PubMed View Article
  
• 作者单位：Suk Woo Lee (1)
  Hyun Hee Jo (2)
  Mee Ran Kim (2)
  Jang Heub Kim (2)
  Young Oak You (3)
  
  1. Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 431-796, Korea
  2. Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul St. Mary鈥檚 Hospital, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea
  3. Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, St. Vincent Hospital, 93 Jungbu-daero, Ji-dong, Paldal-gu, Suwon, Gyeonggi-do, 442-723, Korea
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Objectives Undercarboxylated osteocalcin (ucOC) has been proved as a regulator of glucose and fat mass in an animal model. This study examined the association between osteocalcin and metabolic syndrome (MetS) in postmenopausal women. Methods We selected 135 postmenopausal women and determined anthropometric values [waist-hip ratio (WHR), visceral fat area (VFA), body fat mass (BFM), and skeletal muscle mass (SMM)], the lipid profile, fasting plasma glucose (FPG), insulin, high-sensitivity C-reactive protein (hs-CRP), homeostasis model assessment of insulin resistance (HOMA-IR), serum leptin and adiponectin level, and serum tOC and ucOC level. Results There were 52 postmenopausal women in the MetS group. After adjusting for age and years since menopause, ucOC was negatively correlated with WHR, VFA, BFM, triglyceride, fasting insulin, HOMA-IR, and serum leptin and was positively correlated with serum adiponectin. The odds ratio for MetS was significantly lower in the highest quartile than the lowest quartile after adjusting for age, years since menopause, and BMI. In multiple regression analysis, serum leptin and HOMA-IR were the most important predictors of the independent variables that affect serum ucOC. Conclusion ucOC showed an inverse correlation with markers of insulin resistance, central obesity, and the presence of MetS in postmenopausal women and appears to protect against MetS. Further large-scale clinical and experimental studies are needed to clarify the potential of ucOC as a predictor of MetS in postmenopausal women.