The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo

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• 作者：I. Levinger ; X. Lin ; X. Zhang ; T. C. Brennan-Speranza…
• 关键词：Bone ; muscle interactions ; Glucose uptake ; Insulin sensitivity ; Muscle contraction ; Osteocalcin
• 刊名：Osteoporosis International
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：27
• 期：2
• 页码：653-663
• 全文大小：1,171 KB
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• 作者单位：I. Levinger (1)
  X. Lin (1)
  X. Zhang (1)
  T. C. Brennan-Speranza (2)
  B. Volpato (2)
  A. Hayes (1) (3)
  G. Jerums (4)
  E. Seeman (4)
  G. McConell (1) (3)
  
  1. Clinical Exercise Science Research Program, Institute of Sport, Exercise and Active Living (ISEAL) College of Sport and Exercise Science, Victoria University, PO Box 14428, Melbourne, VIC, 8001, Australia
  2. Department of Physiology and Bosch Institute for Medical Research, University of Sydney, Sydney, Australia
  3. Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Australia
  4. Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Orthopedics
  Gynecology
  Endocrinology
  Rheumatology
  
• 出版者：Springer London
• ISSN：1433-2965

文摘

Summary We tested whether GPRC6A, the putative receptor of undercarboxylated osteocalcin (ucOC), is present in mouse muscle and whether ucOC increases insulin sensitivity following ex vivo muscle contraction. GPPRC6A is expressed in mouse muscle and in the mouse myotubes from a cell line. ucOC potentiated the effect of ex vivo contraction on insulin sensitivity.