Candida galli as a Cause of Tinea Unguium—Molecular Characterization of a Rare Clinical Fungal Entity

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• 作者：Fátima Galán-Sánchez ; Lidia García-Agudo ; Pedro García-Martos…
• 关键词：Candida galli ; Yarrowia ; MALDI–TOF ; Candida lipolytica
• 刊名：Mycopathologia
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：178
• 期：3-4
• 页码：303-306
• 全文大小：173 KB
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• 作者单位：Fátima Galán-Sánchez (1)
  Lidia García-Agudo (1)
  Pedro García-Martos (1)
  Manuel Rodríguez-Iglesias (1)
  
  1. Clinical Microbiology Laboratory, Puerta del Mar University Hospital, Cádiz, Spain
  
• ISSN：1573-0832

文摘

We present the first clinical report of an infection caused by Candida galli, an anamorphic yeast species in the Yarrowia clade. C. galli has been described in the literature only four times, but never before it has been isolated from clinical samples. The colony morphology on Sabouraud medium and morphotype on CHROMagar Candida medium were similar to C. lipolytica as well as the carbon assimilation profile. The phenotypic differences with C. lipolytica were the non-assimilation of N-acetyl glucosamine, the absence of urease activity, growth in 10?% NaCl with 5?% glucose and in vitamin-free medium. MALDI–TOF MS could not generate reliable identification of the strain. Molecular analysis based on amplification of the ITS1-5.8S-ITS2 rDNA regions confirmed the identity as C. galli. Antifungal susceptibility test clearly demonstrated high MICs to 5-fluorocytosine, amphotericin B and fluconazole, as in the species belonging to the Yarrowia clade.