Biodegradable composite scaffolds of bioactive glass/chitosan/carboxymethyl cellulose for hemostatic and bone regeneration

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• 作者：Chen Chen (1)
  Hong Li (2)
  Jianfeng Pan (1)
  Zuoqin Yan (1)
  Zhenjun Yao (1)
  Wenshuai Fan (1)
  Changan Guo (1)
  
  1. Department of Orthopaedics ; Zhongshan Hospital ; Fudan University ; 180 Fenglin Road ; Shanghai ; 200032 ; China
  2. Department of Sports Medicine ; Huashan Hospital ; Shanghai ; China
  
• 关键词：Bioactive glass ; Bone repair ; Bone wax ; Carboxymethyl cellulose ; Chitosan ; Hemostasis
• 刊名：Biotechnology Letters
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：37
• 期：2
• 页码：457-465
• 全文大小：6,295 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Biotechnology
  Applied Microbiology
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-6776

文摘

Hemostasis in orthopedic osteotomy or bone cutting requires different methods and materials. The bleeding of bone marrow can be mostly stopped by bone wax. However, the wax cannot be absorbed, which leads to artificial prosthesis loosening, foreign matter reaction, and infection. Here, a bioactive glass/chitosan/carboxymethyl cellulose (BG/CS/CMC) composite scaffold was designed to replace traditional wax. WST-1 assay indicated the BG/CS/CMC composite resulted in excellent biocompatibility with no cytotoxicity. In vivo osteogenesis assessment revealed that the BG/CS/CMC composite played a dominant role in bone regeneration and hemostasis. The BG/CS/CMC composite had the same hemostasis effect as bone wax; in addition its biodegradation also led to the functional reconstruction of bone defects. Thus, BG/CS/CMC scaffolds can serve as a potential material for bone repair and hemostasis in critical-sized bone defects.