Calcium carbonate-mineralized polymer nanoparticles for pH-responsive robust nanocarriers of docetaxel

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• 作者：Byung Joo Kim (1)
  Kyung Hyun Min (1)
  Gyu Ha Hwang (1)
  Hong Jae Lee (2)
  Seo Young Jeong (1)
  Eun-Cheol Kim (3)
  Sang Cheon Lee (2)
  
  1. Department of Life and Nanopharmaceutical Science ; College of Pharmacy ; Kyung Hee University ; 1 Hoegi-dong ; Dongdaemun-gu ; Seoul ; 130-701 ; Korea
  2. Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology ; School of Dentistry ; Kyung Hee University ; 1 Hoegi-dong ; Dongdaemun-gu ; Seoul ; 130-701 ; Korea
  3. Department of Maxillofacial Tissue Regeneration and Research Center for Tooth and Periodontal Regeneration (MRC) ; School of Dentistry ; Kyung Hee University ; 1 Heogi-dong ; Dongdaemun-gu ; Seoul ; 130-701 ; Korea
  
• 关键词：mineralization ; pH ; responsive ; calcium carbonate ; docetaxel ; intracellular release
• 刊名：Macromolecular Research
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：23
• 期：1
• 页码：111-117
• 全文大小：584 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Physical Chemistry
  Polymer Sciences
  Characterization and Evaluation of Materials
  Soft and Granular Matter, Complex Fluids and Microfluidics
  Nanochemistry
  Nanotec
  
• 出版者：The Polymer Society of Korea, co-published with Springer
• ISSN：2092-7673

文摘

A calcium carbonate (CaCO3)-mineralized core-shell-corona micelle was evaluated as an intracellular nanocarrier of docetaxel (DTX). The polymer micelle consisting of the poly(ethylene glycol) coronal, the anionic poly(L-aspartic acid) middle shell, and the DTX-loaded hydrophobic poly(L-phenylalanine) core was used as a nanotemplate for CaCO3 mineralization was performed by initial electrostatic localization of calcium ions at the anionic PAsp middle shells, and the subsequent addition of carbonate anions to trigger the growth of CaCO3 around the PAsp middle shells. Even after mineralization, the micelle size and the spherical morphology were maintained. The CaCO3-mineralized micelles exhibited enhanced stability against micelle-disrupting surfactants and the serums. The mineralized CaCO3 layer could suppress DTX release efficiently at extracellular pH (7.4) but dissolve at an intracellular endosomal pH (pH ~ 5.0) to facilitate the DTX release. These results reveal the promising potential of CaCO3-mineralized polymer micelle as a stable and effective nanocarrier system in tumor therapy.