Hypertrophic cervical elongation: clinical and histological correlations

详细信息    查看全文

• 作者：Okechukwu A. Ibeanu (1) (2)
  Ralph R. Chesson (1)
  Dane Sandquist (1)
  Javier Perez (1)
  Kerri Santiago (1)
  Thomas E. Nolan (1)
  
• 关键词：Hypertrophic cervical elongation ; Pelvic organ prolapse
• 刊名：International Urogynecology Journal
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：21
• 期：8
• 页码：995-1000
• 全文大小：118KB
• 参考文献：1. Dietz HP (2008) The aetiology of prolapse. Int Urogynecol J 19(10):1323-329 CrossRef
  2. Kerkhof MH, Hendriks L, Br?lmann HA (2009) Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature. Int Urogynecol J 20(4):461-74 CrossRef
  3. American Medical Association (2009) International Classification of Diseases ICD-9-CM, 1:244
  4. Bump RC, Mattiasson A, B? K, Brubaker LP, DeLancey JO, Klarskov P et al (1996) The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 175:10-7 CrossRef
  5. Antovska SV (2008) A new modification of the POPQQ system—its effectiveness in the diagnosis of supravaginal elongation of the uterine cervix in cases with genital prolapse. Bratisl Lek Listy 109(7):307-12
  6. Merriam-Webster Inc. (1986) Webster's medical desk dictionary. Merriam-Webster Inc., Springfield, 315 pp
  7. Lahm A, Uhl M, Lehr HA, Ihling C, Kreuz PC, Haberstroh J (2004) Photoshop-based image analysis of canine articular cartilage after subchondral damage. Arch Orthop Trauma Surg 124(7):431-36 CrossRef
  8. Ludmir J, Sehdev H (2000) Anatomy and physiology of the uterine cervix. Clin Obstet Gynecol 43(3):433-39 CrossRef
  9. Leppert PC, Keller S, Cerreta J, Hosannah Y, Mandl I (1983) The content of elastin in the uterine cervix. Arch Biochem Biophys 222(1):53-8 CrossRef
  10. Leppert PC, Keller S, Cerreta J, Mandl I (1982) Conclusive evidence for the presence of elastin in human and monkey cervix. Am J Obstet Gynecol 142(12):179-82
  11. Soderberg MW, Falconer C, Bystrom B, Malmstrom A, Ekman G (2004) Young women with genital prolapse have a low collagen concentration. Acta Obstet Gynecol Scand 83(12):1193-198
  12. Liapis A, Bakas P, Pafiti A, Frangos-Plemenos M, Arnoyannaki N, Creatsas G (2001) Changes of collagen type III in female patients with genuine stress incontinence and pelvic floor prolapse. Eur J Obstet Gynecol Reprod Biol 97:76-9 CrossRef
  13. Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA (2002) Morphometric properties of the posterior vaginal wall in women with pelvic organ prolapse. Am J Obstet Gynecol 187:1501-509 CrossRef
  14. Phillips CH, Anthony F, Benyon C, Monga AK (2006) Collagen metabolism in the uterosacral ligaments and vaginal skin of women with uterine prolapse. Br J Obstet Gynaecol 113:39-6
  15. Cole EE, Leu PB, Gomelsky A, Revelo P, Shappell H, Scarpero HM et al (2006) Histopathological evaluation of the uterosacral ligament: is this a dependable structure for pelvic reconstruction? Br J Urol 97:345-48
  16. Rahn DD, Ruff MD, Brown SA, Tibbals HF, Word RA (2008) Biomechanical properties of the vaginal wall: effect of pregnancy, elastic fiber deficiency, and pelvic organ prolapse. Am J Obstet Gynecol 198:590e1-90e6 CrossRef
  17. Epstein LB, Graham CA, Heit MH (2007) Systemic and vaginal biomechanical properties of women with normal vaginal support and pelvic organ prolapse. Am J Obstet Gynecol 197:165e1-65e6 CrossRef
  18. Hsu Y, Chen L, Delancey J, Ashton-Miller J (2005) Vaginal thickness, cross-sectional area, and perimeter in women with and those without prolapse. Obstet Gynecol 105:1012-017
  19. Mokrzycki M, Mittal K, Smilen S, Blechman A, Porges R, Demopolous R (1997) Estrogen and progesterone receptors in the uterosacral ligament. Obstet Gynecol 90:402-04 CrossRef
  20. Chung DJ, Bai SW (2006) Roles of sex steroid receptors and cell cycle regulation in pathogenesis of pelvic organ prolapse. Curr Opin Obstet Gynecol 18:551-54 CrossRef
  21. Bakas P, Liapis A, Vlahopoulos S, Giner M, Logotheti S, Creatsas G et al (2008) Estrogen receptor alpha and beta in uterine fibroids: a basis for altered estrogen responsiveness. Fertil Steril 90(5):1878-885 CrossRef
  22. Takacs P, Gualtieri M, Nassiri M, Candiotti K, Medina C (2008) Vaginal smooth muscle cell apoptosis is increased in women with pelvic organ prolapse. Int Urogynecol J 19(11):1559-564 CrossRef
  
• 作者单位：Okechukwu A. Ibeanu (1) (2)
  Ralph R. Chesson (1)
  Dane Sandquist (1)
  Javier Perez (1)
  Kerri Santiago (1)
  Thomas E. Nolan (1)
  
  1. Johns Hopkins University, Baltimore, MD, USA
  2. 600 North Wolfe Street, Phipps 281, Baltimore, MD, 21202, USA
  

文摘

Introduction and hypothesis The objective of this study is to define the diagnosis of hypertrophic cervical elongation clinically and to perform histochemical and histological evaluations of patients with and without hypertrophic cervical elongation. Methods This prospective study was conducted at Louisiana State University between December 2005 and May 2008. Fourteen women with cervical elongation and 28 women without prolapse were studied. Results The amounts of elastin, collagen, and smooth muscle did not differ between study and control groups. Estrogen and progesterone receptor content in cervical elongation were elevated compared to the cervix of women without prolapse. Hypertrophic cervical elongation was defined as the difference between point C and point D of the Pelvic Organ Prolapse Quantification system greater than 8?cm. Conclusions Estrogen and progesterone receptor levels are greater in women with hypertrophic cervical elongation compared with a normal cervix.