参考文献:1. Ishida, T, Joh, T, Uike, N (2012) Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol 30: pp. 837-842 CrossRef 2. Kamihira, S, Dateki, N, Sugahara, K (2003) Significance of HTLV-1 proviral load quantification by real-time PCR as a surrogate marker for HTLV-1-infected cell count. Clin Lab Haematol 25: pp. 111-117 CrossRef 3. Ishii, T, Ishida, T, Utsunomiya, A (2010) Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphoma. Clin Cancer Res 16: pp. 1520-1531 CrossRef 4. Nakayama, T, Hieshima, K, Arao, T (2008) Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. Oncogene 27: pp. 3221-3232 CrossRef 5. Higuchi, T, Nakayama, T, Arao, T, Nishio, K, Yoshie, O (2013) SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma. Blood 121: pp. 3640-3649 CrossRef 6. Hiraga, J, Tomita, A, Sugimoto, T (2009) Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance. Blood 113: pp. 4885-4893 CrossRef 7. Yoshie, O, Fujisawa, R, Nakayama, T (2002) Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. Blood 99: pp. 1505-1511 CrossRef 8. Ohno, N, Kobayashi, S, Ishigaki, T (2013) Loss of CCR4 antigen expression after mogamulizumab therapy in a case of adult T-cell leukaemia-lymphoma. Br J Haematol 163: pp. 683-685 CrossRef