Anti-proliferative and Pro-apoptotic Effect of Dichloromethane Extract of Octopus vulgaris By-Products on Human Breast Cancer Cell Lines

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• 作者：Edda Miray Fitahia (1)
  Christian Edmond Raheriniaina (1)
  Marc Antoine Bazin (3)
  Jean-Michel Huvelin (2)
  C茅dric Log茅 (3)
  Eulalie Ranaivoson (1)
  Hassan Nazih (2) (4)
  
  1. Institut Halieutique et des Sciences Marines ; University of Toliara ; Toliara ; Madagascar
  3. EA 1155 ; Cibles et M茅dicaments des Infections de l鈥檌mmunit茅 et du Cancer ; Faculty of Pharmacy ; University of Nantes ; Nantes ; France
  2. EA-2160 ; MMS 鈥淢er ; Mol茅cules ; Sant茅鈥? Faculty of Pharmacy ; University of Nantes ; Nantes ; France
  4. MMS EA2160 ; 1 Rue Gaston Veil ; Laboratoire de Biochimie ; UFR des Sciences Pharmaceutiques et Biologiques ; 44068 ; Nantes ; France
  
• 关键词：Octopus vulgaris ; By ; products ; Lipids ; Breast cancer
• 刊名：Waste and Biomass Valorization
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：6
• 期：2
• 页码：237-242
• 全文大小：928 KB
• 参考文献：1. The State of World Fisheries and Aquaculture. Food and Agriculture Organization, United Nations, Rome (2014). www.fao.org/3/a-i3720e
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  5. Mendilaharsu, M, Stefani, E, Deneo-Pellegrini, H, Carzoglio, J, Ronco, A (1998) Phytosterols and risk of lung cancer: a case鈥揷ontrol study in Uruguay. Lung Cancer 21: pp. 37-45 CrossRef
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  9. Roz, A, Bard, JM, Huvelin, JM, Nazih, H (2012) LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. Anticancer Res. 32: pp. 3007-3013
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• 刊物类别：Engineering
• 刊物主题：Engineering, general
  Environment
  Waste Management and Waste Technology
  Industrial Pollution Prevention
  Renewable and Green Energy
  Environmental Engineering
  
• 出版者：Springer Netherlands
• ISSN：1877-265X

文摘

Purpose Octopus by-products are considered as a waste and no data of the activity of their lipid fractions have ever been reported. The aim of this study was to valorize Octopus vulgaris by-products by investigating their dichloromethane extract effect on proliferation and apoptosis of human breast cancer cell lines. Methods Two lipidics subfractions, F3336 and F3740, of Octopus by-products were obtained by silica gel chromatography after total lipid extraction. Their effects on proliferation, migration and apoptosis were examined on MCF-7 and MDA-MB-231 human breast cancer cell lines. The 3-(4,5-dimethyl-2-thiazol)-2,5 diphenyltetrazolium bromides (MTT) assay was used for the cell viability. Cell death was determined by flow cytometric analysis after 7-aminoactinomycin D (7-AAD) staining. MDA-MB-231 invasion and migration were analyzed using the Boyden chamber and wound healing assay. Results Treatment with the two lipidics subfractions showed a reduction in the proliferation of MCF-7 and MDA-MB-231 cell lines in a dose dependent manner. Treatments significantly inhibited MCF-7 cells growth than MDA-MB 231 cells. Moreover, the two lipidics subfractions induced apoptosis of MCF-7 cells and reduced invasion and migration of MDA-MB 231 cells. Conclusion This study shows for the first time that O. vulgaris lipid extracts have an antiproliferative and apoptotic effects on human breast cancer cell lines.