Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation

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• 作者：Jacob Haugen ; Martijn L. T. M. Müller ; Vikas Kotagal…
• 关键词：Parkinson disease ; PET ; Olfaction ; Dopamine ; Aging
• 刊名：Journal of Neural Transmission
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：123
• 期：4
• 页码：421-424
• 全文大小：330 KB
• 参考文献：Adler CH, Connor DJ, Hentz JG, Sabbagh MN, Caviness JN, Shill HA, Noble B, Beach TG (2010) Incidental Lewy body disease: clinical comparison to a control cohort. Mov Disord 25(5):642–646. doi:10.​1002/​mds.​22971 CrossRef PubMed PubMedCentral
  Berendse HW, Roos DS, Raijmakers P, Doty RL (2011) Motor and non-motor correlates of olfactory dysfunction in Parkinson’s disease. J Neurol Sci 310(1–2):21–24. doi:10.​1016/​j.​jns.​2011.​06.​020 CrossRef PubMed
  Bohnen NI, Studenski SA, Constantine GM, Moore RY (2008) Diagnostic performance of clinical motor and non-motor tests of Parkinson disease: a matched case-control study. Eur J Neurol 15(7):685–691. doi:10.​1111/​j.​1468-1331.​2008.​02148.​x CrossRef PubMed
  Bohnen NI, Muller MLTM, Kotagal V, Koeppe RA, Kilbourn MA, Albin RL, Frey KA (2010) Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson disease. Brain 133:1747–1754CrossRef PubMed PubMedCentral
  Doty RL, Shaman P, Dann M (1984) Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 32(3):489–502. doi:10.​1016/​0031-9384(84)90269-5 CrossRef PubMed
  Haehner A, Boesveldt S, Berendse HW, Mackay-Sim A, Fleischmann J, Silburn PA, Johnston AN, Mellick GD, Herting B, Reichmann H, Hummel T (2009) Prevalence of smell loss in Parkinson’s disease—a multicenter study. Parkinsonism Relat Disord 15(7):490–494. doi:10.​1016/​j.​parkreldis.​2008.​12.​005 CrossRef PubMed
  Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55(3):181–184CrossRef PubMed PubMedCentral
  Hummel T, Landis BN, Huttenbrink KB (2011) Smell and taste disorders. GMS current topics in otorhinolaryngology, head and neck surgery 10:Doc04. doi:10.​3205/​cto000077 PubMed PubMedCentral
  Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ, Amyloid Biomarker Study G, Aalten P, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BN, Bibeau K, Blennow K, Brooks DJ, van Buchem MA, Camus V, Cavedo E, Chen K, Chetelat G, Cohen AD, Drzezga A, Engelborghs S, Fagan AM, Fladby T, Fleisher AS, van der Flier WM, Ford L, Forster S, Fortea J, Foskett N, Frederiksen KS, Freund-Levi Y, Frisoni GB, Froelich L, Gabryelewicz T, Gill KD, Gkatzima O, Gomez-Tortosa E, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Hildebrandt H, Ishihara L, Ivanoiu A, Jagust WJ, Johannsen P, Kandimalla R, Kapaki E, Klimkowicz-Mrowiec A, Klunk WE, Kohler S, Koglin N, Kornhuber J, Kramberger MG, Van Laere K, Landau SM, Lee DY, de Leon M, Lisetti V, Lleo A, Madsen K, Maier W, Marcusson J, Mattsson N, de Mendonca A, Meulenbroek O, Meyer PT, Mintun MA, Mok V, Molinuevo JL, Mollergard HM, Morris JC, Mroczko B, Van der Mussele S, Na DL, Newberg A, Nordberg A, Nordlund A, Novak GP, Paraskevas GP, Parnetti L, Perera G, Peters O, Popp J, Prabhakar S, Rabinovici GD, Ramakers IH, Rami L, Resende de Oliveira C, Rinne JO, Rodrigue KM, Rodriguez-Rodriguez E, Roe CM, Rot U, Rowe CC, Ruther E, Sabri O, Sanchez-Juan P, Santana I, Sarazin M, Schroder J, Schutte C, Seo SW, Soetewey F, Soininen H, Spiru L, Struyfs H, Teunissen CE, Tsolaki M, Vandenberghe R, Verbeek MM, Villemagne VL, Vos SJ, van Waalwijk van Doorn LJ, Waldemar G, Wallin A, Wallin AK, Wiltfang J, Wolk DA, Zboch M, Zetterberg H (2015) Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. JAMA 313(19):1924–1938. doi:10.​1001/​jama.​2015.​4668
  Lee DH, Oh JS, Ham JH, Lee JJ, Lee I, Lee PH, Kim JS, Sohn YH (2015) Is normosmic Parkinson disease a unique clinical phenotype? Neurology 85(15):1270–1275. doi:10.​1212/​WNL.​0000000000001999​ CrossRef PubMed
  Muller A, Reichmann H, Livermore A, Hummel T (2002) Olfactory function in idiopathic Parkinson’s disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients. J Neural Transm 109(5–6):805–811. doi:10.​1007/​s007020200067 PubMed
  Shah N, Frey KA, Müller MLTM, Petrou M, Kotagal V, Koeppe RA, Scott PJ, Albin RL, Bohnen NI (2016) Striatal and cortical beta-amyloidopathy and cognition in Parkinson’s disease. Mov Disord 31(1):111–117. doi:10.​1002/​mds.​26369 CrossRef PubMed
  Wenning GK, Shephard B, Hawkes C, Petruckevitch A, Lees A, Quinn N (1995) Olfactory function in atypical parkinsonian syndromes. Acta Neurol Scand 91(4):247–250CrossRef PubMed
  
• 作者单位：Jacob Haugen (1)
  Martijn L. T. M. Müller (1) (3)
  Vikas Kotagal (2) (4)
  Roger L. Albin (2) (3) (4)
  Robert A. Koeppe (1)
  Peter J. H. Scott (1)
  Kirk A. Frey (1) (2)
  Nicolaas I. Bohnen (1) (2) (3) (4)
  
  1. Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI, 48105-9755, USA
  3. University of Michigan Morris K. Udall Center of Excellence for Parkinson’s Disease Research, Ann Arbor, MI, USA
  2. Department of Neurology, University of Michigan, Ann Arbor, MI, USA
  4. Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Wien
• ISSN：1435-1463

文摘

There is wide variability in the reported prevalence rates of abnormal smell in Parkinson disease (PD). This study assessed the prevalence of abnormal smell, using the University of Pennsylvania Smell Identification Test (UPSIT), in 183 patients with PD with confirmed PET imaging evidence of nigrostriatal denervation. Impaired olfaction in this sample was nearly universal (97.8 %). Wide-ranging prior olfactory impairment estimates may reflect not only uncertainty regarding diagnostic classification, but also the use of inaccurate normative data and differences in olfactory tests used.