Differentiation Potential of Human Bone Marrow Mesenchymal Stem Cells into Motorneuron-like Cells on Electrospun Gelatin Membrane

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• 作者：Faezeh Faghihi (1)
  Esmaeil Mirzaei (2)
  Arash Sarveazad (3)
  Jafar Ai (4) (5)
  Somayeh Ebrahimi Barough (4)
  Abolfazl Lotfi (6)
  Mohammad Taghi Joghataei (1) (3) (7)
  
  1. Cellular and Molecular Research Center ; Iran University of Medical Sciences ; Tehran ; Iran
  2. Department of Medical Nanotechnology ; School of Advanced Technologies in Medicine ; Tehran University of Medical Sciences ; Tehran ; Iran
  3. Department of Anatomy ; School of Medicine ; Iran University of Medical Sciences ; Tehran ; Iran
  4. Department of Tissue Engineering ; School of Advanced Technologies in Medicine ; Tehran University of Medical Sciences ; Tehran ; Iran
  5. Brain and Spinal Injury Research Center ; Imam Khomeini Hospital ; Tehran University of Medical Sciences ; Tehran ; Iran
  6. Department of Biotechnology ; National Institute of Genetic Engineering and Biotechnology ; Tehran ; Iran
  7. Department of Neuroscience ; School of Advanced Technologies in Medicine ; Iran University of Medical Sciences ; Tehran ; Iran
  
• 关键词：Human bone marrow mesenchymal stem cells ; Motorneuron ; Electrospun gelatin membrane
• 刊名：Journal of Molecular Neuroscience
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：55
• 期：4
• 页码：845-853
• 全文大小：2,889 KB
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• 刊物主题：Neurosciences; Neurochemistry; Cell Biology; Proteomics; Neurology;
• 出版者：Springer US
• ISSN：1559-1166

文摘

Human bone marrow-derived mesenchymal stem cells are potent types of cells with self renewal ability and immunomodulatory properties. They not only have the capacity to differentiate into mesodermal lineages, but they are also capable to transdifferentiate into neural cells in vitro and in vivo. From a biological point of view, the specification of cell fate in the central nervous system is largely dictated by retinoic acid and sonic hedgehog. In addition with inductive molecules, electrospun three dimensional (3D) scaffolds with similar properties to natural extracellular matrix represent a physiological environment that could better resemble the in vivo microenvironment in comparison with two dimensional culture systems. In this regard, the aim of this study was to examine whether induction of human BM-MSCs with retinoic acid (RA) and sonic hedgehog (Shh) in combination with electrospun gelatin scaffold could lead to better differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) into motorneuron-like cells in vitro.