Nucleotide differences of coxsackievirus B3 and chronic myocarditis

详细信息    查看全文

• 作者：Chiharu Kishimoto (1)
  Nami Takamatsu (2)
  Hiroshi Ochiai (2)
  Kagemasa Kuribayashi (3)
  
  1. Department of Cardiovascular Medicine ; Graduate School of Medicine ; Kyoto University ; 54 Kawara-cho ; Shogoin ; Sakyo-ku ; Kyoto ; 606-8507 ; Japan
  2. Department of Human Science ; Faculty of Medicine ; Toyama University ; Toyama ; 930-0194 ; Japan
  3. Department of Bioregulation ; School of Medicine ; Mie University ; Tsu ; 514-8507 ; Japan
  
• 关键词：Myocarditis ; Coxsackievirus B3 ; SCID mouse ; Amyocarditic strain ; Myocarditic strain
• 刊名：Heart and Vessels
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：30
• 期：1
• 页码：126-135
• 全文大小：4,784 KB
• 参考文献：1. Kawai C (1999) From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death: learning from the past for the future. Circulation 99:1091鈥?100 CrossRef
  2. Kishimoto C, Kuribayashi K, Fukuma K, Masuda T, Tomioka N, Abelmann WH, Kawai C (1987) Immunologic identification of lymphocyte subsets in experimental murine myocarditis with encephalomyocarditis virus. Different kinetics of lymphocyte subsets between the heart and the peripheral blood, and significance of Thy 1.2⁺ (pan T) and Lyt 1⁺, 23⁺ (immature T) subsets in the development of myocarditis. Circ Res 61:715鈥?25 CrossRef
  3. Flairwealther D, Rose NR (2007) Coxsackievirus-induced myocarditis in mice. A model of autoimmune disease for studying immunotoxicity. Methods 41:118鈥?22 CrossRef
  4. Westermann D, Savvatis K, Lindner D, Zietsch C, Becher PM, Hammer E, Heimesaat MM, Bereswill S, V枚lker U, Escher F, Riad A, Plendl J, Klingel K, Poller W, Schultheiss HP, Tsch枚pe C (2011) Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy. Circulation 124:2082鈥?093 CrossRef
  5. Corsten MF, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, Summer G, Coort SL, Hazebroek M, van Leeuwen R, Gijbels MJ, Wijnands E, Biessen EA, De Winther MP, Stassen FR, Carmeliet P, Kauppinen S, Schroen B, Heymans S (2012) MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis. Circ Res 111:415鈥?25 CrossRef
  6. Gangaplara A, Massilamany C, Brown DM, Delhon G, Pattnaik AK, Chapman N, Rose N, Steffen D, Reddy J (2012) Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-伪-reactive CD4 T cells in A/J mice. Clin Immunol 144:237鈥?49 CrossRef
  7. Liu W, Moussawi M, Roberts B, Boyson JE, Huber SA (2013) Cross-regulation of T regulatory-cell response after coxsackievirus B3 infection by NKT and 纬未 T cells in the mouse. Am J Pathol 183:441鈥?49 CrossRef
  8. Bosma GC, Custer RP, Bosma MJ (1983) A severe combined immunodeficiency mutation in the mouse. Nature 301:527鈥?30 CrossRef
  9. Phillips RA, Spaner DE (1991) The SCID mouse: mutation in a DNA repair gene creates recipients useful for studies on stem cells, lymphocyte development and graft-versus-host disease. Immunol Rev 124:63鈥?4 CrossRef
  10. Duchosal MA, McConahey PJ, Robinson CA, Dixon FJ (1990) Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice. J Exp Med 172:985鈥?88 CrossRef
  11. Tighe H, Silverman GJ, Kozin F, Tucker R, Gulizia R, Peebles C, Lotz M, Rhodes G, Machold K, Mosier DE, Carson DA (1990) Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients. Eur J Immunol 20:1843鈥?848 CrossRef
  12. Gauntt CJ, Trousdale MD, LaBadie DR, Paque RE, Nealon T (1979) Properties of coxsackievirus B3 variants which are amyocarditic or myocarditic for mice. J Med Virol 3:207鈥?20 CrossRef
  13. Beck MA, Shi Q, Morris VC, Levander OA (1995) Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium deficient mice results in selection of identical virulent isolates. Nat Med 1:433鈥?36 CrossRef
  14. Kishimoto C (1994) Analysis of the pathogenesis of coxsackievirus B3 myocarditis: Comparison of myocarditic and amyocarditic coxsackievirus B3 strains. In: Nagano M, Takeda N, Dhalla NS (eds) The cardiomyopathic hearts. Raven Press, New York, pp 309鈥?12
  15. Takada H, Kishimoto C, Kurokawa M, Hiraoka Y (2003) Amyocarditic coxsackievirus B3 causes myocarditis in immunocompromised mice. Exp Clin Cardiol 8:71鈥?5
  16. Kishimoto C, Hiraoka Y, Takada H (2001) T cell-mediated immune response enhances the severity of myocarditis in secondary cardiotropic virus infection in mice. Basic Res Cardiol 96:436鈥?45 CrossRef
  17. Saito K, Torii M, Ma N, Tsuchiya T, Wang L, Hori T, Nagakubo D, Nitta N, Kanegasaki S, Hieshima K, Yoshie O, Gabazza EC, Katayama N, Shiku H, Kuribayashi K, Kato T (2008) Differential regulatory function of resting and preactivated allergen-specific CD4⁺ CD25⁺ regulatory T cells in Th2-type airway inflammation. J Immunol 181:6889鈥?897 CrossRef
  18. Nishikawa H, Kato T, Tawara I, Ikeda H, Kuribayashi K, Allen PM, Schreiber RD, Old LJ, Shiku H (2005) IFN-gamma controls the generation/activation of CD4⁺ CD25⁺ regulatory T cells in antitumor immune response. J Immunol 175:4433鈥?440 CrossRef
  19. Kishimoto C, Kuroki Y, Hiraoka Y, Ochiai H, Kurokawa M, Sasayama S (1994) Cytokine and murine coxsackievirus B3 myocarditis. Interleukin-2 suppressed myocarditis in the acute stage but enhanced the condition in the subsequent stage. Circulation 89:2836鈥?842 CrossRef
  20. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observation. J Am Stat Assoc 53:457鈥?62
  21. Lindberg AM, St氓lhandske PO, Pettersson U (1987) Genome of coxsackievirus B3. Virology 156:50鈥?3 CrossRef
  22. Klump WM, Bergmann I, M眉ller BC, Ameis D, Kandolf R (1990) Complete nucleotide sequence of infectious coxsackievirus B3 cDNA. Two initial 5鈥?uridine residues are regained during plus-strand RNA synthesis. J Virol 64:1573鈥?583
  23. Yuan Z, Shioji K, Kishimoto C (2003) Immunohistological analyses of myocardial infiltrating cells in various animal models of myocarditis. Exp Clin Cardiol 8:13鈥?6
  24. Kishimoto C, Misaki T, Crumpacker CS, Abelmann WH (1988) Serial immunologic identification of lymphocyte subsets in murine coxsackievirus B3 myocarditis. Different kinetics and significance of lymphocyte subsets in the heart and in peripheral blood. Circulation 77:645鈥?53 CrossRef
  25. Tu Z, Chapman NM, Hufnagel G, Tracy S, Romero JR, Barry WH, Zhao L, Currey K, Shapiro B (1995) The cardiovirulent phenotype of coxsackievirus B3 is determined at a single site in the genomic 5鈥?nontranslated region. J Virol 69:4607鈥?618
  26. Smith SC, Allen PM (1992) Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis. Proc Natl Acad Sci USA 89:9131鈥?135 CrossRef
  27. Cunningham MW, Antone SM, Gulizia JM, McManus BM, Fischetti VA, Gauntt CJ (1992) Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin. Proc Natl Acad Sci USA 89:1320鈥?324 CrossRef
  28. Kishimoto C, Abelmann WH (1990) In vivo significance of T cells in the development of Coxsackievirus B3 myocarditis in mice. Immature but antigen-specific T cells aggravate cardiac injury. Circ Res 67:589鈥?98 CrossRef
  29. Henke A, Huber S, Stelzner A, Whitton JL (1995) The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis. J Virol 69:6720鈥?728
  30. Weinzierl AO, Szalay G, Wolburg H, Sauter M, Rammensee HG, Kandolf R, Stevanovi膰 S, Klingel K (2008) Effective chemokine secretion by dendritic cells and expansion of cross-presenting CD4鈭?CD8+ dendritic cells define a protective phenotype in the mouse model of coxsackievirus myocarditis. J Virol 82:8149鈥?160 CrossRef
  31. Kodama M, Matsumoto Y, Fujiwara M (1992) In vivo lymphocyte mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis. Circulation 85:1918鈥?926 CrossRef
  32. Kodama M, Hanawa H, Saeki M, Hosono H, Inomata T, Suzuki K, Shibata A (1994) Rat dilated cardiomyopathy after autoimmune giant cell myocarditis. Circ Res 75:278鈥?84 CrossRef
  33. Inomata T, Hanawa H, Miyanishi T, Yajima E, Nakayama S, Maita T, Kodama M, Izumi T, Shibata A, Abo T (1995) Localization of porcine cardiac myosin epitopes that induce experimental autoimmune myocarditis. Circ Res 76:726鈥?33
  34. Hanawa H, Inomata T, Sekikawa H, Abo T, Kodama M, Izumi T, Shibata A (1996) Analysis of heart-infiltrating T-cell clonotypes in experimental autoimmune myocarditis in rats. Circ Res 78:118鈥?25 CrossRef
  35. Wegmann KW, ZhaoW Griffin AC, Hickey WF (1994) Identification of myocarditogenic peptides derived from cardiac myosin capable of inducing experimental allergic myocarditis in the Lewis rat. J Immunol 153:892鈥?00
  36. Smith SC, Allen PM (1991) Myosin-induced acute myocarditis is a T cell-mediated disease. J Immunol 147:2141鈥?147
  37. Schwimmbeck PL, Badorff C, Schultheiss HP, Strauer BE (1994) Transfer of human myocarditis into severe combined immunodeficiency mice. Circ Res 75:156鈥?64 CrossRef
  38. Barbaro G (2002) Cardiovascular manifestations of HIV infection. Circulation 106:1420鈥?425 CrossRef
  39. Ntsekhe M, Hakim J (2005) Impact of human immunodeficiency virus infection on cardiovascular disease in Africa. Circulation 112:3602鈥?607 CrossRef
  40. Hufnagel G, Chapman N, Tracy S (1995) A non-cardiovirulent strain of coxsackievirus B3 causes myocarditis in mice with severe combined immunodeficiency syndrome. Eur Heart J 16(Suppl):18鈥?9 CrossRef
  41. Abe T, Tsuda E, Miyazaki A, Ishibashi-Ueda H, Yamada O (2013) Clinical characteristics and long-term outcome of acute myocarditis in children. Heart Vessel 28:632鈥?38 CrossRef
  42. Ishida K, Wada H, Sakakura K, Kubo N, Ikeda N, Sugawara Y, Ako J, Momomura S (2013) Long-term follow-up on cardiac function following fulminant myocarditis requiring percutaneous extracorporeal cardiopulmonary support. Heart Vessel 28:86鈥?0 CrossRef
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Cardiac Surgery
  Vascular Surgery
  Biomedical Engineering
  Interventional Radiology
  Ultrasound
  
• 出版者：Springer Japan
• ISSN：1615-2573

文摘

The in vivo mechanisms in chronic myocarditis remain unclear. The aim of the current study was to clarify the genomic difference of amyocarditic (CB3O) and myocarditic (CB3M) coxsackievirus B3 (CB3) and the pathogenesis of in vivo mechanisms in chronic myocarditis. We examined the histopathology of CB3-inoculated wild-type (WT) and severe combined immunodeficient (SCID) mice with and without adoptive transfer of lymphocytes. There were no differences in viral growth between CB3O and CB3M. There were four to six nucleotide differences in the sequence of CB3O in comparison with the known CB3M. The difference in virus sequence between CB3O and CB3M was very minimal. The changes were located in 1A, 1C, and 1D regions, which encode the structural capsid proteins. Definite myocarditis developed in WT C3H (H-2k) inoculated with CB3M. On the contrary, trivial or mild myocarditis occurred in WT C3H mice inoculated with CB3O. In SCID C3H and SCID C57BL/6 (H-2b) mice, definite myocarditis developed by inoculation with both CB3O and CB3M. Myocardial lesion was less severe in the mice infected with CB3O than in those with CB3M. After anti-CD8 antibody treatment, myocarditis was easily induced in mice originally showing resistance to infection. In addition, chronic myocarditis developed in CB3O-infected SCID C3H mice reconstituted with CB3M-sensitized splenocytes of WT C3H mice. The development of chronic myocarditis primarily depends on the presence or absence of the virus genome, and secondarily on the complex interaction between virus virulence and immunological background of the host. CB3 infection may cause chronic myocarditis with ongoing inflammation with or without viral persistence.