Aggressive transformation of anaplastic large cell lymphoma with increased number of ALK-translocated chromosomes

详细信息    查看全文

• 作者：Akihiro Hoshino (1)
  Keiko Nomura (1)
  Takeru Hamashima (2)
  Tomoya Isobe (3)
  Masafumi Seki (4)
  Mitsuteru Hiwatari (4)
  Kenichi Yoshida (5)
  Yuichi Shiraishi (6)
  Kenichi Chiba (6)
  Hiroko Tanaka (7)
  Satoru Miyano (6) (7)
  Seishi Ogawa (5)
  Junko Takita (4)
  Hirokazu Kanegane (1) (8)
  
  1. Department of Pediatrics ; Graduate School of Medicine and Pharmaceutical Sciences ; University of Toyama ; 2630 Sugitani ; Toyama ; Toyama ; 930-0194 ; Japan
  2. Department of Pathology ; Graduate School of Medicine and Pharmaceutical Sciences ; University of Toyama ; Toyama ; Japan
  3. Student of Tokyo University School of Medicine ; Tokyo ; Japan
  4. Department of Pediatrics ; Graduate School of Medicine ; University of Tokyo ; Tokyo ; Japan
  5. Department of Pathology and Tumor Biology ; Graduate School of Medicine ; Kyoto University ; Kyoto ; Japan
  6. Laboratory of DNA Information Analysis ; Human Genome Center ; Institute of Medical Science ; The University of Tokyo ; Tokyo ; Japan
  7. Laboratory of Sequence Analysis ; Human Genome Center ; Institute of Medical Science ; The University of Tokyo ; Tokyo ; Japan
  8. Department of Pediatrics and Developmental Biology ; Graduate School of Medical and Dental Sciences ; Tokyo Medical and Dental University ; Tokyo ; Japan
  
• 关键词：ALK ; Anaplastic large cell lymphoma ; Aggressive transformation ; RNA sequencing ; TPM3 ; ALK
• 刊名：International Journal of Hematology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：101
• 期：2
• 页码：198-202
• 全文大小：567 KB
• 参考文献：1. Wright D, McKeever P, Carter R. Childhood non-Hodgkin lymphomas in the United Kingdom: findings from the UK Children鈥檚 Cancer Study Group. J Clin Pathol. 1997;50:128鈥?4. CrossRef
  2. Le Deley MC, Reiter A, Williams D, Delsol G, Oschlies I, McCarthy K, et al. Prognostic factors in childhood anaplastic large cell lymphoma: results of a large European intergroup study. Blood. 2008;111:1560鈥?. CrossRef
  3. Chiarle R, Voena C, Ambrogio C, Piva R, Inghirami G. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008;8:11鈥?3. CrossRef
  4. Lamant L, McCarthy K, d鈥橝more E, Klapper W, Nakagawa A, Fraga M, et al. Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study. J Clin Oncol. 2011;29:4669鈥?6. CrossRef
  5. Ait-Tahar K, Damm-Welk C, Burkhardt B, Zimmermann M, Klapper W, Reiter A, et al. Correlation of the autoantibody response to the ALK oncoantigen in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with tumor dissemination and relapse risk. Blood. 2010;115:3314鈥?. CrossRef
  6. Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet. 2013;45:860鈥?. CrossRef
  7. Fabarius A, Leitner A, Hochhaus A, M眉ller MC, Hanfstein B, Haferlach C, et al. Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV. Blood. 2011;118:6760鈥?. CrossRef
  8. Oshikawa G, Kurosu T, Arai A, Murakami N, Miura O. Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation. Cancer Genet Cytogenet. 2010;199:56鈥?1. CrossRef
  9. Ries S, Rnjak L, Mitrovi膰 Z, Kuvezdi膰 KG, Nola M, Suci膰 M. CD13+ anaplastic large cell lymphoma with leukemic presentation and additional chromosomal abnormality. Diagn Cytopathol. 2010;38:141鈥?.
  10. Nguyen JT, Condron MR, Nguyen ND, De J, Medeiros LJ, Padula A. Anaplastic large cell lymphoma in leukemic phase: extraordinarily high white blood cell count. Pathol Int. 2009;59:345鈥?3. CrossRef
  11. Grewal JS, Smith LB, Winegarden JD 3rd, Krauss JC, Tworek JA, Schnitzer B. Highly aggressive ALK-positive anaplastic large cell lymphoma with a leukemic phase and multi-organ involvement: a report of three cases and a review of the literature. Ann Hematol. 2007;86:499鈥?08. CrossRef
  12. Bassan R, Biondi A, Benvestito S, Tini ML, Abbate M, Viero P, et al. Acute undifferentiated leukemia with CD7+ and CD13+ immunophenotype. Lack of molecular lineage commitment and association with poor prognostic features. Cancer. 1992;69:396鈥?04. CrossRef
  13. Piccaluga PP, Tabanelli V, Pileri SA. Molecular genetics of peripheral T-cell lymphomas. Int J Hematol. 2014;99:219鈥?6. CrossRef
  14. Moss茅 YP, Lim MS, Voss SD, Wilner K, Ruffner K, Laliberte J, et al. Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a children鈥檚 oncology group phase 1 consortium study. Lancet Oncol. 2013;14:472鈥?0. CrossRef
  
• 刊物主题：Hematology; Oncology;
• 出版者：Springer Japan
• ISSN：1865-3774

文摘

Pediatric anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) usually has a benign clinical course. A small fraction of patients with ALCL develops an aggressive clinical course; however, its etiology remains unclear. Here we report on an ALK-positive ALCL patient, who had complex translocations with TPM3-ALK revealed by RNA sequencing, with a very aggressive clinical course. On admission, the patient had extraordinarily high white blood cell count with double ALK-translocated chromosomes, and subsequently developed a more aggressive transformation with invasion into multiple organs with triple ALK-translocated chromosomes. The aggressive clinical course may have been related to these additional chromosomal aberrations. Our report provides new insights into the clonal evolution in ALCL and suggests the importance of monitoring examinations including fluorescence in situ hybridization analysis.