Electroacupuncture alleviates retrieval of pain memory and its effect on phosphorylation of cAMP response element-binding protein in anterior cingulate cortex in rats

详细信息    查看全文

• 作者：Jing Sun (1)
  Xiao-mei Shao (1)
  Fang Fang (1)
  Zui Shen (1)
  Yuan-yuan Wu (1)
  Jian-qiao Fang (1)
  
  1. Department of Neurobiology and Acupuncture Research ; The Third Clinical Medical College ; Zhejiang Chinese Medical University ; Hangzhou ; China
  
• 关键词：Electroacupuncture ; Pain memory ; Phosphorylation of cAMP response elment ; binding protein ; Anterior cingulate cortex ; Rat
• 刊名：Behavioral and Brain Functions
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：11
• 期：1
• 全文大小：3,829 KB
• 参考文献：1. Moriarty, O, McGuire, B, Finn, D (2011) The effect of pain on cognitive function: a review of clinical and preclinical research. Prog Neurobiol 93: pp. 385-404 CrossRef
  2. Terry, R, Niven, C, Brodie, E, Jones, R, Prowse, M (2008) Memory for pain? A comparison of nonexperiential estimates and patients' reports of the quality and intensity of postoperative pain. J Pain 9: pp. 342-9 CrossRef
  3. Kissin, I, Freitas, C, Bradley, E (2006) Memory of Pain: The of Perineural Resiniferatoxin. Anesth Analg 103: pp. 721-8 CrossRef
  4. Choi, D, Choi, D, Whittington, R, Nedeljkovic, S (2007) Sudden amnesia resulting in pain relief: the relationship between memory and pain. Pain 132: pp. 206-10 CrossRef
  5. Ji, R, Kohno, T, Moore, K, Woolf, C (2003) Central sensitization and LTP: do pain and memory share similar mechanisms?. Trends Neurosci 26: pp. 696-705 CrossRef
  6. Wei, F, Zhuo, M (2008) Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain. Mol Pain 4: pp. 28 CrossRef
  7. Becerra, L, Navratilova, E, Porreca, F, Borsook, D (2013) Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans. J Neurophysiol 110: pp. 1221-6 CrossRef
  8. Yan, N, Cao, B, Xu, J, Hao, C, Zhang, X, Li, Y (2012) Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats. Neurobiol Learn Mem 97: pp. 156-64 CrossRef
  9. Kim, J, Kwon, J, Kim, H, Han, J (2013) CREB and neuronal selection for memory trace. Frontiers Neural Circuits 7: pp. 1-7 CrossRef
  10. Toyoda, H, Zhao, M, Mercaldo, V, Chen, T, Descalzi, G, Kida, S (2010) Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice. Mol Brain 3: pp. 27 CrossRef
  11. Silva, A, Kogan, J, Frankland, P, Kida, S (1998) CREB and memory. Neurosci Biobehav Rev 21: pp. 127-48 CrossRef
  12. Roy, A, Jana, M, Corbett, G, Ramaswamy, S, Kordower, J, Gonzalez, F (2013) Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor alpha. Cell Reports 4: pp. 724-37 CrossRef
  13. Ikeda, H, Mochizuki, K, Murase, K (2013) Astrocytes are involved in long-term facilitation of neuronal excitation in the anterior cingulate cortex of mice with inflammatory pain. Pain 154: pp. 2836-43 CrossRef
  14. Sandkuhler, J, Lee, J (2013) How to erase memory traces of pain and fear. Trends Neurosci 36: pp. 343-52 CrossRef
  15. Ren, X, Lutfy, K, Mangubat, M, Ferrini, M, Lee, M, Liu, Y (2013) Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes 2013: pp. 1-11 CrossRef
  16. Huang, C, Chen, H, Su, H, Hsieh, C, Chen, W, Lai, Z (2013) Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia. Evid-based Complement Altern Med: eCAM 2013: pp. 1-8
  17. Fang, J, Du, J, Liang, Y, Fang, J (2013) Intervention of electroacupuncture on spinal p38 MAPK/ATF-2/VR-1 pathway in treating inflammatory pain induced by CFA in rats. Mol Pain 9: pp. 1-13 CrossRef
  18. Su, T, Zhang, L, Peng, M, Wu, C, Pan, W, Tian, B (2011) Cannabinoid CB2 receptors contribute to upregulation of beta-endorphin in inflamed skin tissues by electroacupuncture. Mol Pain 7: pp. 98 CrossRef
  19. He, T, Yang, W, Zhang, S, Zhang, C, Li, L, Chen, Y (2011) Electroacupuncture inhibits inflammation reaction by upregulating vasoactive intestinal Peptide in rats with adjuvant-induced arthritis. Evid-based Complement Altern Med: eCAM 2011: pp. 1-8
  20. Li, X, Guo, F, Zhang, Q, Huo, T, Liu, L, Wei, H (2014) Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice. BMC Complement Altern Med 14: pp. 1-37 CrossRef
  21. Xu, M, Zhang, S, Zhao, D, Liu, C, Li, C, Chen, C (2013) Electroacupuncture-Induced Neuroprotection against Cerebral Ischemia in Rats: Role of the Dopamine D2 Receptor. Evid-based Complement Altern Med: eCAM 2013: pp. 1-10
  22. Han, X, Zhao, X, Lu, M, Liu, F, Guo, F, Zhang, J (2013) Electroacupuncture Ameliorates Learning and Memory via Activation of the CREB Signaling Pathway in the Hippocampus to Attenuate Apoptosis after Cerebral Hypoperfusion. Evid-based Complement Altern Med: eCAM 2013: pp. 1-8
  23. Wang, L, Tang, C (2004) Effects of Electroacupuncture on Learning, Memory and Formation System of Free Radicals in Brain Tissues of Vascular Dementia Model Rats. J Traditional Chin Med 24: pp. 140-3
  24. Otti, A, Noll-Hussong, M (2012) Acupuncture-induced pain relief and the human brain's default mode network - an extended view of central effects of acupuncture analgesia. Forschende Komplementarmedizin 19: pp. 197-201 CrossRef
  25. Liang, Y, Fang, J, Du, J, Fang, J (2012) Effect of Electroacupuncture on Activation of p38MAPK in Spinal Dorsal Horn in Rats with Complete Freund's Adjuvant-Induced Inflammatory Pain. Evid-based Complement Altern Med: eCAM 2012: pp. 1-6
  26. Wu, F, Pan, R, Yu, W, Liu, R (2014) The Anti-Nociception Effect of Dezocine in a Rat Neuropathic Pain Model. Transl Perioper Pain Med 1: pp. 5-8
  27. Chaplan, SR, Bach, FW, Pogrel, JW, Chung, JM, Yaksh, TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53: pp. 55-63 CrossRef
  28. Cao, H, Gao, Y, Ren, W, Li, T, Duan, K, Cui, Y (2009) Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain. J Neurosci 29: pp. 3307-21 CrossRef
  29. Jantsch, H, Gawlitza, M, Geber, C, Baumgartner, U, Kramer, H, Magerl, W (2009) Explicit episodic memory for sensory-discriminative components of capsaicin-induced pain: immediate and delayed ratings. Pain 143: pp. 97-105 CrossRef
  30. Bouffard, J, Bouyer, L, Roy, J, Mercier, C (2014) Tonic pain experienced during locomotor training impairs retention despite normal performance during acquisition. J Neurosci 34: pp. 9190-5 CrossRef
  31. Melemedjian, O, Tillu, D, Asiedu, M, Mandell, E, Moy, J, Blute, V (2013) BDNF regulates atypical PKC at spinal synapse to initiate and maintain a centralized chronic pain state. Mol Pain 9: pp. 1-14
  32. Walter, S, Lei脽ner, N, Jerg-Bretzke, L, Hrabal, V, Traue, H (2010) Pain and emotional processing in psychological trauma schmeerz und emotionaler verarbeitung im psychologischen traumata. Psychiatr Danub 22: pp. 465-70
  33. Qiu, S, Li, X, Zhuo, M (2011) Post-translational modification of NMDA receptor GluN2B subunit and its roles in chronic pain and memory. Semin Cell Dev Biol 22: pp. 521-9 CrossRef
  34. Wang, Z, Bradesi, S, Charles, J, Pang, R, Maarek, J, Mayer, E (2011) Functional brain activation during retrieval of visceral pain-conditioned passive avoidance in the rat. Pain 152: pp. 2746-56 CrossRef
  35. Wu, L, Zhang, X, Fukushima, H, Zhang, F, Wang, H, Toyoda, H (2008) Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. Eur J Neurosci 27: pp. 1923-32 CrossRef
  36. Terry, R, Brodie, E, Niven, C (2007) Exploring the Phenomenology of Memory for Pain: Is Previously Experienced Acute Pain Consciously Remembered or Simply Known?. J Pain 8: pp. 467-75 CrossRef
  37. Vogt, B (2005) Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 6: pp. 533-44 CrossRef
  38. Li, X, Wang, N, Wang, Y, Zuo, Z, Koga, K, Luo, F (2014) Long-term temporal imprecision of information coding in the anterior cingulate cortex of mice with peripheral inflammation or nerve injury. J Neurosci 34: pp. 10675-87 CrossRef
  39. Kim, HN, Kim, YR, Jang, JY, Shin, HK, Choi, BT (2012) Electroacupuncture inhibits phosphorylation of spinal phosphatidylinositol 3-kinase/Akt in a carrageenan-induced inflammatory rat model. Brain Res Bull 87: pp. 199-204 CrossRef
  40. Descalzi, G, Fukushima, H, Suzuki, A, Kida, S, Zhuo, M (2012) Genetic enhancement of neuropathic and inflammatory pain by forebrain upregulation of CREB-mediated transcription. Mol Pain 8: pp. 1-6
  41. Han, J, Kushner, S, Yiu, A, Hsiang, H, Buch, T, Waisman, A (2009) Selective erasure of a fear memory. Science 323: pp. 1492-6 CrossRef
  42. Mogil, J, McCarson, K (2000) Identifying pain genes: Bottom-up and top-down approaches. J Pain 1: pp. 66-80 CrossRef
  43. Carlezon, W, Duman, R, Nestler, E (2005) The many faces of CREB. Trends Neurosci 28: pp. 436-45 CrossRef
  44. Edelmayer, R, Brederson, J, Jarvis, M, Bitner, R (2014) Biochemical and pharmacological assessment of MAP-kinase signaling along pain pathways in experimental rodent models: a potential tool for the discovery of novel antinociceptive therapeutics. Biochem Pharmacol 87: pp. 390-8 CrossRef
  45. Zhang, N, Wen, Q, Ren, L, Liang, W, Xia, Y, Zhang, X (2013) Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells. Int J Mol Sci 14: pp. 18657-69 CrossRef
  46. Kelley, J, Anderson, K, Altmann, S, Itzhak, Y (2011) Long-term memory of visually cued fear conditioning: roles of the neuronal nitric oxide synthase gene and cyclic AMP response element-binding protein. Neuroscience 174: pp. 91-103 CrossRef
  47. Viosca, J, Armentia, M, Jancic, D, Barco, A (2009) Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory. Learn Mem 16: pp. 193-7 CrossRef
  48. Bozon, B, Kelly, A, Josselyn, S, Silva, A, Davis, S, Laroche, S (2003) MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos Trans R Soc Lond Ser B Biol Sci 358: pp. 805-14 CrossRef
  49. Dworkin, S, Heath, J, Jong-Curtain, T, Hogan, B, Lieschke, G, Malaterre, J (2007) CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish. Dev Biol 307: pp. 127-41 CrossRef
  50. Lonze, B, Ginty, D (2002) Function and Regulation of CREB Family Transcription Factors in the Nervous System. Neuron 35: pp. 605-23 CrossRef
  51. Morris, K, Gold, P (2012) Age-related impairments in memory and in CREB and pCREB expression in hippocampus and amygdala following inhibitory avoidance training. Mech Ageing Dev 133: pp. 291-9 CrossRef
  52. Orlando, U, Cooke, M, Maciel, F, Papadopoulos, V, Podesta, E, Maloberti, P (2013) Characterization of the mouse promoter region of the acyl-CoA synthetase 4 gene: role of Sp1 and CREB. Mol Cell Endocrinol 369: pp. 15-26 CrossRef
  53. Heinrich, A, Heyde, A, Boer, U, Phu, D, Tzvetkov, M, Oetjen, E (2013) Lithium enhances CRTC oligomer formation and the interaction between the CREB coactivators CRTC and CBP鈥搃mplications for CREB-dependent gene transcription. Cell Signal 25: pp. 113-25 CrossRef
  54. Mizuno, M, Yamada, K, Maekawa, N, Saito, K, Seishima, M, Nabeshima, T (2002) CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. Behav Brain Res 133: pp. 135-41 CrossRef
  55. Xue, H, Qiao, Y, Ni, P, Wang, J, Chen, C, Huang, G (2011) A CRE that binds CREB and contributes to PKA-dependent regulation of the proximal promoter of human RAB25 gene. Int J Biochem Cell Biol 43: pp. 348-57 CrossRef
  56. Cammarota, M, Bevilaqua, L, Ardenghi, P, Paratcha, G, Stein, M, Izquierdo, I (2000) Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade. Mol Brain Res 76: pp. 36-46 CrossRef
  57. Rogge, G, Jones, D, Green, T, Nestler, E, Kuhar, M (2009) Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo. Brain Res 1251: pp. 42-52 CrossRef
  58. Guan, C, Cui, Y, Sun, G, Yu, F, Tang, C, Li, Y (2009) Role of CREB in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells. Regul Pept 153: pp. 64-9 CrossRef
  59. Chen, F, Dong, Y, Zhang, Z, Cao, D, Xu, J, Hui, J (2012) Activation of astrocytes in the anterior cingulate cortex contributes to the affective component of pain in an inflammatory pain model. Brain Res Bull 87: pp. 60-6 CrossRef
  60. Zhuo, M (2008) Cortical excitation and chronic pain. Trends Neurosci 31: pp. 199-207 CrossRef
  61. Nimmerjahn, A, Kirchhoff, F, Helmchen, F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308: pp. 1314-8 CrossRef
  62. Scholz, J, Woolf, C (2007) The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 10: pp. 1361-8 CrossRef
  63. Rossi, D, Brady, J, Mohr, C (2007) Astrocyte metabolism and signaling during brain ischemia. Nat Neurosci 10: pp. 1377-86 CrossRef
  64. Hanisch, U, Kettenmann, H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: pp. 1387-94 CrossRef
  65. Ren, K, Dubner, R (2008) Neuron-glia crosstalk gets serious: role in pain hypersensitivity. Curr Opin Anaesthesiol 21: pp. 570-9 CrossRef
  
• 刊物主题：Neurosciences; Neurology; Behavioral Therapy;
• 出版者：BioMed Central
• ISSN：1744-9081

文摘

Background Recent evidence suggests that persistent pain and recurrent pain are due to the pain memory which is related to the phosphorylation of cAMP response element-binding protein (p-CREB) in anterior cingulate cortex (ACC). Eletroacupuncture (EA), as a complementary Chinese medical procedure, has a significant impact on the treatment of pain and is now considered as a mind-body therapy. Methods The rat model of pain memory was induced by two injections of carrageenan into the paws, which was administered separately by a 14-day interval, and treated with EA therapy. The paw withdrawal thresholds (PWTs) of animals were measured and p-CREB expressions in ACC were detected by using immunofluorescence (IF) and electrophoretic mobility shift assay (EMSA). Statistical comparisons among different groups were made by one-way, repeated-measures analysis of variance (ANOVA). Results The second injection of carrageenan caused the decrease of PWTs in the non-injected hind paw. EA stimulation applied prior to the second injection, increased the values of PWTs. In ACC, the numbers of p-CREB positive cells were significantly increased in pain memory model rats, which were significantly reduced by EA. EMSA results showed EA also down-regulated the combining capacity of p-CREB with its DNA. Furthermore, the co-expression of p-CREB with GFAP, OX-42, or NeuN in ACC was strengthened in the pain memory model rats. EA inhibited the co-expression of p-CREB with GFAP or OX-42, but not NeuN in ACC. Conclusions The present results suggest the retrieval of pain memory could be alleviated by the pre-treatment of EA, which is at least partially attributed to the down-regulated expression and combining capacity of p-CREB and the decreased expression of p-CREB in astrocytes and microglia cells.