Evaluation of Rapid Diagnostic Methods of Urinary Protein Estimation in Patients of Preeclampsia of Advanced Gestational Age

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• 作者：Archana Kumari (1)
  Abha Singh (1)
  Ritu Singh (2)
  
• 关键词：Preeclampsia ; Spot UPCR ; 24 h urine protein ; Dipstick method
• 刊名：The Journal of Obstetrics and Gynecology of India
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：63
• 期：5
• 页码：306-310
• 全文大小：
• 作者单位：Archana Kumari (1)
  Abha Singh (1)
  Ritu Singh (2)
  
  1. Department of Obstetrics and Gynaecology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
  2. Department of Biochemistry, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
  
• ISSN：0975-6434

文摘

Background 24-h urine protein is traditionally used as a gold standard method for protein estimation. Because of the operational difficulty, there is the necessity to use rapid, convenient, and reliable method of proteinuria estimation. Aim We carried out this study to compare the two rapid methods of protein estimation: dipstick method and spot urine protein creatinine ratio (UPCR) with that of 24-h urine protein in patients of preeclampsia with advanced gestational period. Methodology The values of proteinuria estimated by dipstick method and spot UPCR were compared with that of 24-h urine protein. The strength of correlation was measured by Pearson correlation coefficient (r). A p value of <0.05 is considered to be statistically significant. The most discriminant spot UPCR value for detecting significant proteinuria (00mg/day) was determined by plotting receiverperator curve (ROC). Result The value of spot UPCR strongly correlated with 24-h urine protein (r=0.88 with p value <0.001). The most discriminant spot UPCR value for detecting significant proteinuria (00mg/day) was 0.3. The estimation of proteinuria by dipstick method was poorly correlated with 24-h urine protein with r=0.09. Conclusion Spot UPCR can be used as a rapid and reliable alternative method in preference to 24-h proteinuria in patients of preeclampsia of advanced gestational age.