USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage

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• 作者：Zhiwei Xu ; Xiaohong Li ; Jianping Chen ; Jianmei Zhao…
• 关键词：Intracerebral hemorrhage ; USP11 ; Neuronal apoptosis
• 刊名：Journal of Molecular Neuroscience
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：58
• 期：1
• 页码：16-27
• 全文大小：4,988 KB
• 参考文献：Al-Salihi MA, Herhaus L, Macartney T, Sapkota GP (2012) USP11 augments TGFbeta signalling by deubiquitylating ALK5. Open Biol 2:120063PubMedCentral CrossRef PubMed
  Andrews CM, Jauch EC, Hemphill JC, Smith WS 3rd, Weingart SD (2012) Emergency neurological life support: intracerebral hemorrhage. Neurocrit Care 17(Suppl 1):S37–S46CrossRef PubMed
  Ardizzone TD, Zhan X, Ander BP, Sharp FR (2007) SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage. Stroke 38:1621–1625CrossRef PubMed
  Aronowski J, Zhao X (2011) Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. Stroke 42:1781–1786PubMedCentral CrossRef PubMed
  Babu R, Bagley JH, Di C, Friedman AH, Adamson C (2012) Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage-induced secondary brain injury and as potential targets for intervention. Neurosurg Focus 32:E8CrossRef PubMed
  Balami JS, Buchan AM (2012) Complications of intracerebral haemorrhage. Lancet Neurol 11:101–118CrossRef PubMed
  Bayraktar S et al (2013) USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancer. Cancer J 19:10–17PubMedCentral CrossRef PubMed
  Belayev L et al (2007) Experimental intracerebral hematoma in the rat: characterization by sequential magnetic resonance imaging, behavior, and histopathology. Effect of albumin therapy. Brain Res 1157:146–155CrossRef PubMed
  Brnjic S et al (2014) Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress. Antioxid Redox Signal 21:2271–2285PubMedCentral CrossRef PubMed
  Cajigas IJ, Will T, Schuman EM (2010) Protein homeostasis and synaptic plasticity. EMBO J 29:2746–2752PubMedCentral CrossRef PubMed
  Caldeira MV, Salazar IL, Curcio M, Canzoniero LM, Duarte CB (2014) Role of the ubiquitin-proteasome system in brain ischemia: friend or foe? Prog Neurobiol 112:50–69CrossRef PubMed
  Cernochova D, Pospisilova E, Nepozitkova D, Havelka P, Lichnovsky V (1999) Apoptosis and expression of proliferative proteins in the developing nervous system and orofacial region of human embryos. Gen Physiol Biophys 18(Suppl 1):90–93PubMed
  Chan WY, Yew DT (1998) Apoptosis and Bcl-2 oncoprotein expression in the human fetal central nervous system. Anat Rec 252:165–175CrossRef PubMed
  Chen PC, Qin LN, Li XM, Walters BJ, Wilson JA, Mei L, Wilson SM (2009) The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions. J Neurosci 29:10909–10919PubMedCentral CrossRef PubMed
  Cregan SP, MacLaurin JG, Craig CG, Robertson GS, Nicholson DW, Park DS, Slack RS (1999) Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J Neurosci 19:7860–7869PubMed
  D’Amelio M, Sheng M, Cecconi F (2012) Caspase-3 in the central nervous system: beyond apoptosis. Trends Neurosci 35:700–709CrossRef PubMed
  Dowlatshahi D, Hogan MJ, Sharma M, Stotts G, Blacquiere D, Chakraborty S (2013) Ongoing bleeding in acute intracerebral haemorrhage. Lancet 381:152CrossRef PubMed
  Egashira Y, Hua Y, Keep RF, Xi G (2015) Intercellular cross-talk in intracerebral hemorrhage. Brain Res
  Gautschi OP, Schaller K (2013) Surgery or conservative therapy for cerebral haemorrhage? Lancet 382:377–378CrossRef PubMed
  Glickman MH, Ciechanover A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82:373–428CrossRef PubMed
  Ideguchi H et al (2002) Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. Biochem J 367:87–95PubMedCentral CrossRef PubMed
  Katsuda K et al (2002) Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells. Oncogene 21:2108–2113CrossRef PubMed
  Ke JY et al (2014) USP11 regulates p53 stability by deubiquitinating p53. J Zhejiang Univ Sci B 15:1032–1038PubMedCentral CrossRef PubMed
  Keep RF, Hua Y, Xi G (2012) Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol 11:720–731CrossRef PubMed
  Lee EW, Seong D, Seo J, Jeong M, Lee HK, Song J (2015) USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics. Cell Death Differ
  Li K, Cao RJ, Zhu XJ, Liu XY, Li LY, Cui SS (2015) Erythropoietin attenuates the apoptosis of adult neurons after brachial plexus root avulsion by downregulating JNK phosphorylation and c-Jun expression and inhibiting c-PARP cleavage. J Mol Neurosci
  Maertens GN, El Messaoudi-Aubert S, Elderkin S, Hiom K, Peters G (2010) Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J 29:2553–2565PubMedCentral CrossRef PubMed
  Mahoney DJ et al (2008) Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc Natl Acad Sci U S A 105:11778–11783PubMedCentral CrossRef PubMed
  Mendelow AD, Gregson BA, Rowan EN, Murray GD, Gholkar A, Mitchell PM, Investigators SI (2013) Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial. Lancet 382:397–408PubMedCentral CrossRef PubMed
  Pierfelice TJ, Schreck KC, Eberhart CG, Gaiano N (2008) Notch, neural stem cells, and brain tumors. Cold Spring Harb Symp Quant Biol 73:367–375PubMedCentral CrossRef PubMed
  Schoenfeld AR, Apgar S, Dolios G, Wang R, Aaronson SA (2004) BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. Mol Cell Biol 24:7444–7455PubMedCentral CrossRef PubMed
  Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009) Defining the human deubiquitinating enzyme interaction landscape. Cell 138:389–403PubMedCentral CrossRef PubMed
  Wagener FA et al (2001) Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood 98:1802–1811CrossRef PubMed
  Walters BJ et al (2008) Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity. Mol Cell Neurosci 39:539–548PubMedCentral CrossRef PubMed
  Wang J (2010) Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol 92:463–477PubMedCentral CrossRef PubMed
  Wu HC et al (2014) USP11 regulates PML stability to control Notch-induced malignancy in brain tumours. Nat Commun 5:3214PubMed
  Xue M, Del Bigio MR (2000) Intracerebral injection of autologous whole blood in rats: time course of inflammation and cell death. Neurosci Lett 283:230–232CrossRef PubMed
  Yamaguchi T, Kimura J, Miki Y, Yoshida K (2007) The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha). J Biol Chem 282:33943–33948CrossRef PubMed
  Yang S, Song S, Hua Y, Nakamura T, Keep RF, Xi G (2008) Effects of thrombin on neurogenesis after intracerebral hemorrhage. Stroke 39:2079–2084CrossRef PubMed
  Yoon K, Gaiano N (2005) Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat Neurosci 8:709–715CrossRef PubMed
  Zhou Y, Wang Y, Wang J, Anne Stetler R, Yang QW (2014) Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation. Prog Neurobiol 115:25–44CrossRef PubMed
  
• 作者单位：Zhiwei Xu (1)
  Xiaohong Li (2)
  Jianping Chen (2)
  Jianmei Zhao (2)
  Jun Wang (2)
  Yuhong Ji (1)
  Yifen Shen (1)
  Lijian Han (1)
  Jiansheng Shi (2)
  Dongmei Zhang (1)
  
  1. Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, 226001, Jiangsu Province, China
  2. Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, People’s Republic of China
  
• 刊物主题：Neurosciences; Neurochemistry; Cell Biology; Proteomics; Neurology;
• 出版者：Springer US
• ISSN：1559-1166

文摘

Protein ubiquitination is a dynamic two-way process that can be reversed or regulated by deubiquitinating enzymes (DUB). USP11, located on the X chromosome, 6 is a member of USP subclass of the DUB family. Here, we demonstrate that USP11 may be involved in neuronal apoptosis in the processes of intracerebral hemorrhage (ICH). From the results of Western blot, immunohistochemistry, and immunofluorescence, we obtained a significant up-regulation of USP11 in neurons adjacent to the hematoma following ICH. Increasing USP11 level was found to be accompanied by the up-regulation of active caspase-3, Fas receptor (Fas), Fas ligand (FasL), and active caspase-8. Besides, USP11 co-localized well with active caspase-3 in neurons, indicating its potential role in neuronal apoptosis. What is more, knocking down USP11 by RNA-interference in PC12 cells reduced active caspase-3 expression. Thus, USP11 may play a role in promoting the brain secondary damage following ICH.