State of research in the field of the creation of plant vaccines for veterinary use

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• 作者：N. V. Permyakova ; E. A. Uvarova ; E. V. Deineko
• 关键词：transgenic plants ; plant vaccines ; biosafety ; expression systems ; recombinant proteins ; veterinary
• 刊名：Russian Journal of Plant Physiology
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：62
• 期：1
• 页码：23-38
• 全文大小：774 KB
• 参考文献：1. Rybicki, E.P., Plant-produced vaccines: promise and reality, / Drug Discov. Today, 2009, vol. 14, pp. 16-4. CrossRef
  2. Thomas, D.R., Penney, C.A., Majumder, A., and Walmsley, A.M., Evolution of plant-made pharmaceuticals, / Int. J. Mol. Sci., 2011, vol. 12, pp. 3220-236. CrossRef
  3. Meeusen, E.N.T., Walker, J., Peters, A., Pastoret, P.-P., and Jungersen, G., Current status of veterinary vaccines, / Clin. Microbiol. Rev., 2007, vol. 20, pp. 489-10. CrossRef
  4. Hefferon, K., Clinical trials fuel the promise of plantderived vaccines, / Am. J. Chin. Med., 2010, vol. 7, pp. 30-7.
  5. Mason, H.S., Lam, M.-K.D., and Arntzen, C.J., Expression of hepatitis B surface antigen in transgenic plants, / Proc. Natl. Acad. Sci. USA, 1992, vol. 89, pp. 11745-1749. CrossRef
  6. Haq, T., Mason, H.S., Clements, J.D., and Arntzen, C.J., Oral immunization with a recombinant bacterial antigen produced in transgenic plants, / Science, 1995, vol. 268, pp. 714-16. CrossRef
  7. Mason, H.S., Haq, T.A., Clements, J.D., and Arntzen, C.J., Edible vaccine protects mice against / Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene, / Vaccine, 1998, vol. 16, pp. 1336-343. CrossRef
  8. Arakawa, T., Chong, D.K.X., and Langridge, W., Efficacy of food plant-based oral cholera toxin B subunit vaccine, / Nat. Biotechnol., 1998, vol. 16, pp. 292-97. CrossRef
  9. Tacket, C.O., Mason, H.S., Losonsky, G., Clements, J.D., Levine, M.M., and Arntzen, C.J., Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato, / Nat. Med., 1998, vol. 4, pp. 607-09. CrossRef
  10. Limaye, A., Koya, V., Samsam, M., and Daniell, H., Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system, / FASEB J., 2006, vol. 20, pp. 959-61. CrossRef
  11. Pelosi, A., Shepherd, R., and Walmsley, A.M., Delivery of plant-made vaccines and therapeutics, / Biotechnol. Adv., 2012, vol. 30, pp. 440-48. CrossRef
  12. Lawson, L.B., Norton, E.B., and Clements, J.D., Defending the mucosa: adjuvant and carrier formulations for mucosal immunity, / Curr. Opin. Immunol., 2011, vol. 23, pp. 414-20. CrossRef
  13. Brandtzaeg, P., Induction of secretory immunity and memory at mucosal surfaces, / Vaccine, 2007, vol. 25, pp. 5467-484. vaccine.2006.12.001" target="_blank" title="It opens in new window">CrossRef
  14. Kwon, K.C., Verma, D., Singh, N.D., Herzog, R., and Daniell, H., Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells, / Adv. Drug Deliv. Rev., 2012, vol. 65, pp. 782-99. CrossRef
  15. Hefferon, K.L., The mucosal immune response to plant-derived vaccines, / Pharm. Res., 2010, vol. 27, pp. 2040-042. CrossRef
  16. Gomord, V. and Faye, L., Posttranslational modification of therapeutic proteins in plants, / Curr. Opin. Plant Biol., 2004, vol. 7, pp. 171-81. CrossRef
  17. Boothe, J., Nykiforuk, C., Shen, Y., Zaplachinski, S., Szarka, S., Kuhlman, P., Murray, E., Morck, D., and Moloney, M.M., Seed-based expression systems for plant molecular farming, / Plant Biotechnol. J., 2010, vo
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Plant Physiology
  Plant Sciences
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3407

文摘

Transgenic plants as an alternative of costly systems of recombinant immunogenic protein expression are the source for the production of cheap and highly efficient biotherapeuticals of new generation, including plant vaccines. In the present review, possibilities of plant system application for the production of recombinant proteins for veterinary use are considered, the history of the “edible vaccine-concept is briefly summarized, advantages and disadvantages of various plant systems for the expression of recombinant immunogenic proteins are discussed. The list of recombinant plant vaccines for veterinary use, which are at different stages of clinical trials, is presented.