Chitosan as an adjuvant for parenterally administered inactivated influenza vaccines

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• 作者：Y. Ghendon ; S. Markushin ; G. Krivtsov and I. Akopova
• 刊名：Archives of Virology
• 出版年：2008
• 出版时间：May, 2008
• 年：2008
• 卷：153
• 期：5
• 页码：831-837
• 全文大小：337.3 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Virology
  Medical Microbiology
  Infectious Diseases
  
• 出版者：Springer Wien
• ISSN：1432-8798

文摘

The addition of 0.5% of a chitosan derivative to inactivated influenza vaccines injected parenterally resulted in a four or six to tenfold increase in antibody titres after a single-dose or two-dose intramuscular immunization of mice, respectively, in comparison with antibody titres after immunization without chitosan. Chitosan-adjuvanted vaccines enhanced antibody titers against drift variants of A- and B-type human influenza viruses four to six times compared with the vaccines without chitosan. Inactivated avian influenza virus A/H5N2 admixed with chitosan, when administered to mice challenged afterwards with the same virus, showed higher immunogenicity and protective efficacy compared with the antigen without chitosan.