Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants

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• 作者：Koji Kashima ; Yoshikazu Yuki ; Mio Mejima ; Shiho Kurokawa ; Yuji Suzuki…
• 关键词：GMP production ; Molecular farming ; MucoRice ; Oral vaccine ; Seed bank
• 刊名：Plant Cell Reports
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：35
• 期：3
• 页码：667-679
• 全文大小：778 KB
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• 作者单位：Koji Kashima (1) (2)
  Yoshikazu Yuki (1) (3)
  Mio Mejima (1) (4)
  Shiho Kurokawa (1) (4)
  Yuji Suzuki (1) (4)
  Satomi Minakawa (1) (4)
  Natsumi Takeyama (1) (5)
  Yoshiko Fukuyama (1)
  Tatsuhiko Azegami (1)
  Takeshi Tanimoto (4)
  Masaharu Kuroda (6)
  Minoru Tamura (2)
  Yasuyuki Gomi (4)
  Hiroshi Kiyono (1) (3)
  
  1. Division of Mucosal Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan
  2. Engineering Headquarters, Asahi Kogyosha Co., Ltd., 3-13-12, Mita, Minato-ku, Tokyo, 108-0073, Japan
  3. International Research and Development Center for Mucosal Vaccine, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan
  4. Seto Center, Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, 4-1-70, Seto-Cho, Kanonji, Kagawa, 768-0065, Japan
  5. Research Department, Nippon Institute for Biological Science, 9-2221-1, Shin-machi, Ome, Tokyo, 198-0024, Japan
  6. Crop Development Division, NARO Agriculture Research Center, 1-2-1, Inada, Joetsu-shi, Niigata, 943-0193, Japan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Plant Sciences
  Biotechnology
  Plant Biochemistry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-203X

文摘

Key message The first Good Manufacturing Practices production of a purification-free rice-based oral cholera vaccine (MucoRice-CTB) from transgenic plants in a closed cultivation system yielded a product meeting regulatory requirements.